Two New Spirobiflavonoids from Abies chensiensis with Moderate NO Production Inhibitory Activity

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	Two New Spirobiflavonoids from Abies chensiensis with Moderate NO Production Inhibitory Activity
	Zhang, WD; Li, YL; Huang, DS; Yang, XW; Li, SM; Tang, J; Tian, JM; Peng, XY; yangxw76@163.com
刊名	PLANTA MEDICA
	2009
卷号	75 期号:14 页码:1534-1537
关键词	Abies Chensiensis Pinaceae Spirobiflavonoids Larixinol Raw 264.7 Macrophages No
ISSN号	0032-0943
英文摘要	Phytochemical investigation of the aerial parts of Abies chensiensis afforded two new (compounds 2 and 3) and 27 known compounds, including the related compound larixinol (1). The structures of spirobiflavonoids 1-3 were established using 1D and 2D NMR spectroscopic techniques. In addition, the structure of larixinol (1) was confirmed by X-ray crystallographic analysis. Compounds 1-3 were evaluated for inhibitory activities against LPS-induced NO production in macrophages. Larixinol (1) showed moderate effects, with an IC50 value of 60.0 mu g/mL. In addition, it did not show any cytotoxicity on RAW 264.7 macrophages at 100 mu g/mL.
学科主题	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
URL标识	查看原文
资助项目	LMB
WOS记录号	WOS:000272183500014
公开日期	2011-07-03
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/5046]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
通讯作者	yangxw76@163.com
推荐引用方式 GB/T 7714	Zhang, WD,Li, YL,Huang, DS,et al. Two New Spirobiflavonoids from Abies chensiensis with Moderate NO Production Inhibitory Activity[J]. PLANTA MEDICA,2009,75(14):1534-1537.
APA	Zhang, WD.,Li, YL.,Huang, DS.,Yang, XW.,Li, SM.,...&yangxw76@163.com.(2009).Two New Spirobiflavonoids from Abies chensiensis with Moderate NO Production Inhibitory Activity.PLANTA MEDICA,75(14),1534-1537.
MLA	Zhang, WD,et al."Two New Spirobiflavonoids from Abies chensiensis with Moderate NO Production Inhibitory Activity".PLANTA MEDICA 75.14(2009):1534-1537.