The hepatoprotective and antifibrotic effects of Saururus chinensis against carbon tetrachloride induced hepatic fibrosis in rats

CORC > 南海海洋研究所 > 中国科学院南海海洋研究所 > 中科院海洋生物资源可持续利用重点实验室

	The hepatoprotective and antifibrotic effects of Saururus chinensis against carbon tetrachloride induced hepatic fibrosis in rats
	Cheng, DY; Wang, LS; Wang, HS; Di, L; Zhou, XF; Xu, TH; Yang, XW; Liu, YH; yonghongliu@scsio.ac.cn
刊名	JOURNAL OF ETHNOPHARMACOLOGY
	2009
卷号	126 期号:3 页码:487-491
关键词	Saururus Chinensis Liver Fibrosis Carbon Tetrachloride Hepatoprotective Antifibrotic Effect
ISSN号	0378-8741
英文摘要	Ethnopharmacological relevance: Saururus chinensis (Lour.) Bail] (Saururaceae) has been used in Chinese folk medicine for treatment of various diseases, such as edema,jaundice, gonorrhea, antipyretic, diuretic, and antiinflammatory agents. Aim of the study: Our aim was to evaluate the hepato protective and antifibrotic effects of Saururus chinensis extract (SC-E) in carbon tetrachloride (CCl4) induced liver fibrosis rats. Materials and methods: The SC-E (70 mg/kg) was administrated via gavage once a day starting from the onset Of CCl4 treatment (14 weeks) for subsequent 8 weeks. Evaluated with liver index, serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), hyaluronic acid (HA), hepatic malondialdehyde (MDA) content, and superoxide dismutase (SOD) activity, total cholesterol (TC), triglyceride (TG), total lipoprotein (TP), albumin (ALB), hydroxyproline (HYP), total antioxidant capacity (T-AOC), laminin (LN), type III collagen terminal peptide (PC-IIINP), and type IV collagen (IV-C), as well as with histopathologic changes of liver. Results: SC-E effectively reduced the elevated levels of liver index, serum ALT, AST, HA, and hepatic MDA contents, enhance the reduced hepatic SOD activity in CCl4-treated rats. The histopathological analysis suggested that SC-E obviously alleviated the degree of liver fibrosis induced by CCl4. Conclusions: Those results suggest SC-E has protective and therapeutic effects on liver fibrosis induced by CCl4. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
学科主题	Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
URL标识	查看原文
资助项目	LMB
WOS记录号	WOS:000273157900018
公开日期	2011-07-03
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/5034]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
通讯作者	yonghongliu@scsio.ac.cn
推荐引用方式 GB/T 7714	Cheng, DY,Wang, LS,Wang, HS,et al. The hepatoprotective and antifibrotic effects of Saururus chinensis against carbon tetrachloride induced hepatic fibrosis in rats[J]. JOURNAL OF ETHNOPHARMACOLOGY,2009,126(3):487-491.
APA	Cheng, DY.,Wang, LS.,Wang, HS.,Di, L.,Zhou, XF.,...&yonghongliu@scsio.ac.cn.(2009).The hepatoprotective and antifibrotic effects of Saururus chinensis against carbon tetrachloride induced hepatic fibrosis in rats.JOURNAL OF ETHNOPHARMACOLOGY,126(3),487-491.
MLA	Cheng, DY,et al."The hepatoprotective and antifibrotic effects of Saururus chinensis against carbon tetrachloride induced hepatic fibrosis in rats".JOURNAL OF ETHNOPHARMACOLOGY 126.3(2009):487-491.