Polyhydroxy Steroids and Saponins from China Sea Starfish Asterina pectinifera and Their Biological Activities

CORC > 南海海洋研究所 > 中国科学院南海海洋研究所 > 中科院海洋生物资源可持续利用重点实验室

	Polyhydroxy Steroids and Saponins from China Sea Starfish Asterina pectinifera and Their Biological Activities
	Peng, Y; Zheng, JX; Huang, RM; Wang, YF; Xu, TH; Zhou, XF; Liu, QY; Zeng, FL; Ju, HQ; Yang, XW
刊名	CHEMICAL & PHARMACEUTICAL BULLETIN
	2010
卷号	58 期号:6 页码:856-858
关键词	Asterina Pectinifera Starfish Polyhydroxy Sterol Ester Antiviral Cytotoxicity
ISSN号	0009-2363
英文摘要	A new polyhydroxy sterol ester, (25S)-5 alpha-cholestane-3 beta,6 alpha,7 alpha,8,15 beta,16 beta-hexahydroxyl-26-O-14'Z-eicosenoate (1), together with seven known steroid derivatives (2-8), were isolated from the EtOH extract of the whole body of China Sea starfish Asterina pectinifera. The structure of 1 was determined by using extensive spectra analysis (IR, 1D and 2D NMR, and MS), chemical degradation, and comparison with the known compound (25S)-5 alpha-cholestane-3 beta 6 alpha,7 alpha,8,15 alpha,16 beta,26-heptol (2). All the isolates were evaluated for their antiviral activity against herpes simplex virus type 1 (HSV-1) and their cytotoxicity against human liver carcinoma HepG2 cell line in vitro. Compounds 3-6, and 8 exhibited antiviral activity against HSV-1 virus with the minimal inhibitory concentration (MIC) values of 0.2, 0.05, 0.2, 0.22, and 0.07 mu(M), respectively. While compounds 4 and 5 exhibited cytotoxicity against HepG2 cells with IC50 values of 0.2 and 1.6 mu(M), respectively.
学科主题	Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
URL标识	查看原文
资助项目	LMB
WOS记录号	WOS:000278131700015
公开日期	2011-07-02
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/3830]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
通讯作者	yonghongliu@scsio.ac.cn
推荐引用方式 GB/T 7714	Peng, Y,Zheng, JX,Huang, RM,et al. Polyhydroxy Steroids and Saponins from China Sea Starfish Asterina pectinifera and Their Biological Activities[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2010,58(6):856-858.
APA	Peng, Y.,Zheng, JX.,Huang, RM.,Wang, YF.,Xu, TH.,...&yonghongliu@scsio.ac.cn.(2010).Polyhydroxy Steroids and Saponins from China Sea Starfish Asterina pectinifera and Their Biological Activities.CHEMICAL & PHARMACEUTICAL BULLETIN,58(6),856-858.
MLA	Peng, Y,et al."Polyhydroxy Steroids and Saponins from China Sea Starfish Asterina pectinifera and Their Biological Activities".CHEMICAL & PHARMACEUTICAL BULLETIN 58.6(2010):856-858.