Diterpenoid Constituents of the Roots of Salvia digitaloides

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	Diterpenoid Constituents of the Roots of Salvia digitaloides
	Peng, LY; qinshizhao@mail.kib.ac.cn; xugang008@mail.kib.ac.cn; Zhao, QS; Li, Y; Liu, ED; Pan, ZH; Yang, XW; Wang, YY; Yang, J
刊名	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
	2010
卷号	58 期号:23 页码:12157-12161
关键词	Salvia Digitaloides Cytotoxic Activity Diterpenoids Stereochemistry
ISSN号	0021-8561
英文摘要	Salvia digitaloides, belonging to the economically and medicinally important genus Salvia, is distributed in the northwest of Yunnan Province, People's Republic of China. The roots of this plant were soaked in alcohol by local Tibetans to make a special traditional "red wine", and many local people like to drink this traditional "red wine" to strengthen physical health. To investigate the bioactive diterpenoid constituents of the roots, a detailed phytochemical study was carried out, and 13 diterpenoids including two new norditerpenoids, dihydroneotanshinlactone (1) and 16,17-dinorpisferal A (2), were isolated. Their structures were established on the basis of detailed spectroscopic analysis. In addition, computational methods were applied to validate the stereochemistry of compound 1. For the bioassay to inhibit the growth of five tumor cell lines, neotanshinlactone (3) exhibited selective cytotoxic activity toward the human breast cancer cell line SK-BR-3, while the other four tanshinones (4-7) showed significant toxicity effects against all of the tested five cell lines.
学科主题	Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
URL标识	查看原文
资助项目	LMB
WOS记录号	WOS:000284672800015
公开日期	2011-07-02
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/3722]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
通讯作者	qinshizhao@mail.kib.ac.cn; xugang008@mail.kib.ac.cn
推荐引用方式 GB/T 7714	Peng, LY,qinshizhao@mail.kib.ac.cn,xugang008@mail.kib.ac.cn,et al. Diterpenoid Constituents of the Roots of Salvia digitaloides[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2010,58(23):12157-12161.
APA	Peng, LY.,qinshizhao@mail.kib.ac.cn.,xugang008@mail.kib.ac.cn.,Zhao, QS.,Li, Y.,...&Xu, G.(2010).Diterpenoid Constituents of the Roots of Salvia digitaloides.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,58(23),12157-12161.
MLA	Peng, LY,et al."Diterpenoid Constituents of the Roots of Salvia digitaloides".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 58.23(2010):12157-12161.