Dereplication and targeted isolation of bioactive sulphur compound from bacteria isolated from a hydrothermal field

doi:10.1080/14786419.2017.1399382

CORC > 南海海洋研究所 > 中国科学院南海海洋研究所 > 中科院海洋生物资源可持续利用重点实验室

	Dereplication and targeted isolation of bioactive sulphur compound from bacteria isolated from a hydrothermal field
	Liu, Yonghong ; Lin, Xiuping ; Li, Kunlong 1; Yang, Lilin 3; Peng, Xiaoying 4; Fang, Wei 2; Tian, Xinpeng ; Zhou, Xuefeng
刊名	NATURAL PRODUCT RESEARCH
	2019
卷号	33 期号:4 页码:494
关键词	Hydrothermal bacteria dereplication targeted isolation antivirus butyrolactone I 3-sulphate
ISSN号	1478-6419
DOI	10.1080/14786419.2017.1399382
英文摘要	Marine micro-organisms in the deep-sea hydrothermal vent systems are considered as potential sources of bioactive natural products. Sixteen bacterial strains were isolated from a deep-sea hydrothermal field and screened for bioactive metabolism studies. After the strains were subjected to bioactive testing at different culture media, chemical dereplication by HPLC coupled to high-resolution mass spectrometer was performed to analyse or determine the main secondary metabolisms in those strains. Strain 06204 was large-scale fermented with relative optimal media, for isolating the desired sulphur compound. Butyrolactone I 3-sulphate was isolated and structurally identified from the extract, guided by dereplication and showed moderate antivirus activities against H3N2 and EV71 viruses. Our study suggests that deep-sea hydrothermal bacteria are good sources of sulphur natural products. Meanwhile, the described approach, mainly bioactive screening, dereplication and targeted isolation, is effective and efficient to discover interesting bioactive compounds in hydrothermal bacteria. [GRAPHICS] .
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/17898]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
作者单位	1.Chinese Acad Sci, Guangdong Key Lab Marine Materia Med, Key Lab Trop Marine Bioresources & Ecol, South China Sea Inst Oceanol,RNAM Ctr Marine Micr, Guangzhou, Guangdong, Peoples R China 2.Univ Chinese Acad Sci, Coll Earth Sci, Beijing, Peoples R China 3.Hubei Acad Agr Sci, Hubei Biopesticide Engn Res Ctr, Wuhan, Hubei, Peoples R China 4.Guangzhou 6 Middle Sch, Guangzhou, Guangdong, Peoples R China 5.Shenzhen Univ, Shenzhen, Peoples R China
推荐引用方式 GB/T 7714	Liu, Yonghong,Lin, Xiuping,Li, Kunlong,et al. Dereplication and targeted isolation of bioactive sulphur compound from bacteria isolated from a hydrothermal field[J]. NATURAL PRODUCT RESEARCH,2019,33(4):494, 499.
APA	Liu, Yonghong.,Lin, Xiuping.,Li, Kunlong.,Yang, Lilin.,Peng, Xiaoying.,...&Zhou, Xuefeng.(2019).Dereplication and targeted isolation of bioactive sulphur compound from bacteria isolated from a hydrothermal field.NATURAL PRODUCT RESEARCH,33(4),494.
MLA	Liu, Yonghong,et al."Dereplication and targeted isolation of bioactive sulphur compound from bacteria isolated from a hydrothermal field".NATURAL PRODUCT RESEARCH 33.4(2019):494.