Pharmacokinetics of Florfenicol in the Orange-spotted Grouper, Epinephelus coioides, Following Oral Administration in Warm Seawater

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	Pharmacokinetics of Florfenicol in the Orange-spotted Grouper, Epinephelus coioides, Following Oral Administration in Warm Seawater
	Ruan, Hui-Ting ; Dong, Jun-De ; Luo, Jun-Zhi ; Feng, Jing-Bin ; Chen, Hai-Gang
刊名	JOURNAL OF THE WORLD AQUACULTURE SOCIETY
	2018
卷号	49 期号:6 页码:1058
关键词	absorption distribution elimination florfenicol grouper pharmacokinetics
ISSN号	0893-8849
英文摘要	Pharmacokinetics of florfenicol were studied in the orange-spotted grouper, Epinephelus coioides, at 29.0 +/- 1.0 C following oral administration of 5 or 10 mg/kg. Rapid absorption occurred, with a T-max (time to reach the maximum concentration) of 2-12 h in plasma, muscle, skin, liver, bile, intestine, kidney, and gill. The absorption rate appeared to decrease with increasing dosage, according to the observed T-max in plasma, muscle, skin, liver, and kidney. The maximum concentration (C-max) in plasma was 6.04 +/- 1.11 and 13.01 +/- 6.18 mu g/mL at 5 and 10 mg/kg, respectively, and was lower than that in the intestine but higher than in the other six tissues. A similar absorption and availability was found between the two doses by comparison of the ratios of area under the concentration-time curve (AUC) and dose among the tissues. A relatively low distribution level occurred in extravascular tissues based on the AUC values, with the exception of bile and intestine. The shortest and longest elimination half-life (T-1/2 beta) occurred in plasma (8.51 and 9.34 h at 5 and 10 mg/kg) and bile (18.13 and 17.63 h at 5 and 10 mg/kg), respectively. The elimination rate from plasma, muscle, and kidney was more rapid at 5 than at 10 mg/kg, according to the T-1/2 beta; however, the opposite situation was observed in the remaining five tissues.
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/17597]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
作者单位	1.[Feng, Jing-Bin 2.Chinese Acad Sci, South China Sea Inst Oceanol, Trop Marine Biol Res Stn Hainan, Sanya 572000, Peoples R China 3.[Ruan, Hui-Ting 4.South China Agr Univ, Dept Aquaculture, Coll Anim Sci, Guangzhou 510640, Guangdong, Peoples R China 5.Chinese Acad Fishery Sci, South China Fisheries Inst, Guangdong Prov Key Lab Fishery Ecol & Environm, Guangzhou 510300, Guangdong, Peoples R China 6.[Feng, Jing-Bin 7.Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Appl Marine Biol Guangdong Prov LAMB, Guangzhou 510301, Guangdong, Peoples R China 8.[Feng, Jing-Bin 9.Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol LMB, Guangzhou 510301, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Ruan, Hui-Ting,Dong, Jun-De,Luo, Jun-Zhi,et al. Pharmacokinetics of Florfenicol in the Orange-spotted Grouper, Epinephelus coioides, Following Oral Administration in Warm Seawater[J]. JOURNAL OF THE WORLD AQUACULTURE SOCIETY,2018,49(6):1058, 1067.
APA	Ruan, Hui-Ting,Dong, Jun-De,Luo, Jun-Zhi,Feng, Jing-Bin,&Chen, Hai-Gang.(2018).Pharmacokinetics of Florfenicol in the Orange-spotted Grouper, Epinephelus coioides, Following Oral Administration in Warm Seawater.JOURNAL OF THE WORLD AQUACULTURE SOCIETY,49(6),1058.
MLA	Ruan, Hui-Ting,et al."Pharmacokinetics of Florfenicol in the Orange-spotted Grouper, Epinephelus coioides, Following Oral Administration in Warm Seawater".JOURNAL OF THE WORLD AQUACULTURE SOCIETY 49.6(2018):1058.