Genome Mining for Mycemycin: Discovery and Elucidation of Related Methylation and Chlorination Biosynthetic Chemistries

CORC > 南海海洋研究所 > 中国科学院南海海洋研究所 > 中科院海洋生物资源可持续利用重点实验室

	Genome Mining for Mycemycin: Discovery and Elucidation of Related Methylation and Chlorination Biosynthetic Chemistries
	Huang, Hongbo ; Yang, Zhijie 1; Zhang, Chunyan 1; Ma, Junying ; Sun, Changli ; Ju, Jianhua 1; Li, Qinglian ; Qin, Xiangjing
刊名	ORGANIC LETTERS
	2018
卷号	20 期号:23 页码:7633
ISSN号	1523-7060
英文摘要	A silent dibenzoxazepinone (DBP) biosynthetic gene cluster (myc) was mutagenically activated in Streptomyces olivaceus SCSIO T05, enabling the discovery of mycemycin C (4) and three new analogues [mycemycins F-H (1-3)]. Gene disruption, complementation experiments, and enzymatic assays unveiled salicylic acid and 5-Cl-kynurenine as biosynthetic precursors and shed significant functional insights into MycO, MycB, MycR, and MycJ, enzymes responsible for fine-tuning of the DBP scaffold.
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/17594]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
作者单位	1.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China 2.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Huang, Hongbo,Yang, Zhijie,Zhang, Chunyan,et al. Genome Mining for Mycemycin: Discovery and Elucidation of Related Methylation and Chlorination Biosynthetic Chemistries[J]. ORGANIC LETTERS,2018,20(23):7633, 7636.
APA	Huang, Hongbo.,Yang, Zhijie.,Zhang, Chunyan.,Ma, Junying.,Sun, Changli.,...&Qin, Xiangjing.(2018).Genome Mining for Mycemycin: Discovery and Elucidation of Related Methylation and Chlorination Biosynthetic Chemistries.ORGANIC LETTERS,20(23),7633.
MLA	Huang, Hongbo,et al."Genome Mining for Mycemycin: Discovery and Elucidation of Related Methylation and Chlorination Biosynthetic Chemistries".ORGANIC LETTERS 20.23(2018):7633.