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	Radix Angelicae Sinensis and Radix Hedysari enhance radiosensitivity of C-12(6+) radiation in human liver cancer cells by modulating apoptosis protein
	Kou, Wei1; Li, Ying-Dong1,2; Liu, Kai2; Sun, Shao-Bo2; Dong, Yu-Mei2; Wu, Zhen-Hua3,4
刊名	SAUDI MEDICAL JOURNAL
	2014-09-01
卷号	35期号:9页码:945-952
ISSN号	0379-5284
通讯作者	Li, Ying-Dong(yxkw@xbmu.edu.cn)
英文摘要	Objectives: To investigate the radiosensitizing effects of Radix Angelicae Sinensis-Radix Hedysari (RAS-RH [an ultra-filtration extract]) and its underlying mechanisms in human liver cancer cells H22. Methods: This study was conducted between September 2010 and August 2012 in the Gansu University of Traditional Chinese Medicine, Lanzhou, China. The groups were assigned as the control group, drug (RAS-RH) group, C-12(6+) radiation group, and combination group. The cell counting kit-8 assay, colony formation assay, cell cycle changes, and apoptosis analysis were carried out, and survivin and casepase-9 were evaluated by reverse transcription polymerase chain reaction and Western blot analyses in the 4 groups. Results: The inhibitory effect of RAS-RH on H22 cells was dependent on both concentration and time, RAS-RH was able to enhance the radiosensitivity of H22 cells by increasing cell survival fraction and radiosensitization parameters. Apoptosis and the gap2/mitosis (G2/M) phase transition induced by C-12(6+) heavy ion radiation was enhanced by RAS-RH treatment. Irradiation, combined with RAS-RH, decreased survivin expression while increasing casepase-9 expression in H22 cells. Conclusion: The RAS-RH increased the radiosensitivity of H22 cells of C-12(6+) heavy ion radiation significantly, and its possible mechanism of radiosensitization is to enhance caspase-dependent apoptosis through the down-regulation of survivin, thus, it can be used as an effective radiosensitizer.
收录类别	SCI
WOS关键词	ENERGETIC HEAVY-IONS ; HEPATOCELLULAR-CARCINOMA ; SIGNAL-TRANSDUCTION ; SURVIVIN GENE ; CYCLE ; ACTIVATION ; EXPRESSION ; CASPASE-9 ; POLYMORPHISMS ; FIBROBLASTS
WOS研究方向	General & Internal Medicine
WOS类目	Medicine, General & Internal
语种	英语
出版者	SAUDI MED J
WOS记录号	WOS:000343245700002
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2557864
专题	寒区旱区环境与工程研究所
通讯作者	Li, Ying-Dong
作者单位	1.Lanzhou Univ, Sch Basic Med Sci, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Key Lab TCM Prevent & Control Chron Dis Gansu Pro, Lanzhou, Peoples R China 3.Chinese Acad Sci, Gansu Coll Tradit Chinese Med, Lanzhou, Peoples R China 4.Chinese Acad Sci, Inst Modern Phys, Lanzhou, Peoples R China
推荐引用方式 GB/T 7714	Kou, Wei,Li, Ying-Dong,Liu, Kai,et al. Radix Angelicae Sinensis and Radix Hedysari enhance radiosensitivity of C-12(6+) radiation in human liver cancer cells by modulating apoptosis protein[J]. SAUDI MEDICAL JOURNAL,2014,35(9):945-952.
APA	Kou, Wei,Li, Ying-Dong,Liu, Kai,Sun, Shao-Bo,Dong, Yu-Mei,&Wu, Zhen-Hua.(2014).Radix Angelicae Sinensis and Radix Hedysari enhance radiosensitivity of C-12(6+) radiation in human liver cancer cells by modulating apoptosis protein.SAUDI MEDICAL JOURNAL,35(9),945-952.
MLA	Kou, Wei,et al."Radix Angelicae Sinensis and Radix Hedysari enhance radiosensitivity of C-12(6+) radiation in human liver cancer cells by modulating apoptosis protein".SAUDI MEDICAL JOURNAL 35.9(2014):945-952.

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