| Suppression of E. multilocularis Hydatid Cysts after Ionizing Radiation Exposure | |
| Zhou, Xin1,2,3; Zhao, Yumin4; Zhou, Rong1,2,3; Zhang, Hong1,2,3 | |
| 刊名 | PLOS NEGLECTED TROPICAL DISEASES
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| 2013-10-01 | |
| 卷号 | 7期号:10页码:6 |
| ISSN号 | 1935-2735 |
| DOI | 10.1371/journal.pntd.0002518 |
| 通讯作者 | Zhou, Xin() |
| 英文摘要 | Background: Heavy-ion therapy has an advantage over conventional radiotherapy due to its superb biological effectiveness and dose conformity in cancer therapy. It could be a potential alternate approach for hydatid cyst treatment. However, there is no information currently available on the cellular and molecular basis for heavy-ion irradiation induced cell death in cystic echinococcosis. Methododology/Principal Findings: LD50 was scored by protoscolex death. Cellular and ultrastructural changes within the parasite were studied by light and electron microscopy, mitochondrial DNA (mtDNA) damage and copy number were measured by QPCR, and apoptosis was determined by caspase 3 expression and caspase 3 activity. Ionizing radiation induced sparse cytoplasm, disorganized and clumped organelles, large vacuoles and devoid of villi. The initial mtDNA damage caused by ionizing radiation increased in a dose-dependent manner. The kinetic of DNA repair was slower after carbon-ion radiation than that after X-rays radiation. High dose carbon-ion radiation caused irreversible mtDNA degradation. Cysts apoptosis was pronounced after radiation. Carbon-ion radiation was more effective to suppress hydatid cysts than X-rays. Conclusions: These studies provide a framework to the evaluation of attenuation effect of heavy-ion radiation on cystic echinococcosis in vitro. Carbon-ion radiation is more effective to suppress E. multilocularis than X-rays. |
| 收录类别 | SCI |
| WOS关键词 | CARBON ION RADIOTHERAPY ; OXIDATIVE STRESS ; THERAPY ; APOPTOSIS ; TOXICITY |
| WOS研究方向 | Infectious Diseases ; Parasitology ; Tropical Medicine |
| WOS类目 | Infectious Diseases ; Parasitology ; Tropical Medicine |
| 语种 | 英语 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| WOS记录号 | WOS:000330376500047 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2557854 |
| 专题 | 寒区旱区环境与工程研究所 |
| 通讯作者 | Zhou, Xin |
| 作者单位 | 1.Chinese Acad Sci, Dept Heavy Ion Radiat Med, Inst Modern Phys, Lanzhou, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Peoples R China 3.Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou, Peoples R China 4.Guilin Med Univ, Dept Parasitol, Guilin, Guangxi, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Xin,Zhao, Yumin,Zhou, Rong,et al. Suppression of E. multilocularis Hydatid Cysts after Ionizing Radiation Exposure[J]. PLOS NEGLECTED TROPICAL DISEASES,2013,7(10):6. |
| APA | Zhou, Xin,Zhao, Yumin,Zhou, Rong,&Zhang, Hong.(2013).Suppression of E. multilocularis Hydatid Cysts after Ionizing Radiation Exposure.PLOS NEGLECTED TROPICAL DISEASES,7(10),6. |
| MLA | Zhou, Xin,et al."Suppression of E. multilocularis Hydatid Cysts after Ionizing Radiation Exposure".PLOS NEGLECTED TROPICAL DISEASES 7.10(2013):6. |
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