A pressure-driven gas-diffusion/permeation micropump for self-activated sample transport in an extreme micro-environment

doi:10.1039/c8an01120f

CORC > 长春光学精密机械与物理研究所 > 中国科学院长春光学精密机械与物理研究所

	A pressure-driven gas-diffusion/permeation micropump for self-activated sample transport in an extreme micro-environment
	Wu, Wenming
刊名	ANALYST
	2018-10-21
卷号	143 期号:20 页码:4819-4835
ISSN号	0003-2654
DOI	10.1039/c8an01120f
通讯作者	Wu, Wenming(wuwm@ciomp.ac.cn)
英文摘要	The micropump is the most important functional unit of a micro total analysis system (TAS). An ideal microfluidics system should adopt simple, stable, robust, inexpensive, and integrated on-chip strategies to transport samples for downstream applications, with little or no external energy consumption and limited manual intervention. Nevertheless, it remains a key challenge for traditional micropumps to be directly integrated into self-contained and disposable TAS for velocity-stable and passive sample transport. The best way to assess the capability of passive micropumps is to evaluate their pumping performance in extreme environments, e.g. a 3D configurated microchannel instead of a 2D configuration, high temperature conditions instead of at room temperature, a long microchannel instead of short microchannel, a complex topological microsystem (e.g. a microvascular network interconnecting multiple inlets and outlets) instead of a simple topological microsystem (e.g. a one-directional microchannel connecting only one inlet and one outlet), and multi-phase microdroplet transport instead of single-phase plug transport. In this review, a novel micropumping methodology - a pressure-driven gas-diffusion/permeation micropump - is described, which is the first review paper dedicated to this subject. A comprehensive overview is provided for comparison between this novel micropumping methodology and traditional passive micropumps, especially for applications in stable velocity control in the aforementioned extreme environments. Compared with mainstream conventional micropumps, we confirm that pressure-driven gas-diffusion/permeation micropumps combine a number of superior properties all into one device, such as small size, simple structure, without the need for microfabrication procedures or external power consumption, strong transport capacity, homogeneous flow velocity, delivery capacity for both multi-phase microdroplets and single-phase plugs, long-distance transport, persistent pumping for both 3D microchannels and complex topological microsystems (e.g. a biomimetic microvasculature), low cost, ease of microdevice integration, bubble suppression and amazing stability at high temperatures. An advanced outlook and perspectives for the future development of this novel micropump are also discussed, which may serve as a starting point for researchers in the microfluidics fields to harness pressure-driven gas-diffusion/permeation micropumps for downstream applications.
资助项目	CAS Pioneer Hundred Talents Program ; National Natural Science Foundation of China[61704169] ; Natural Science Foundation of Jilin Province[20180520112JH] ; talent project of Jilin Province
WOS关键词	POLYMERASE-CHAIN-REACTION ; MICROFLUIDIC DEVICES ; CAPILLARY-DRIVEN ; SINGLE HEATER ; DIGITAL PCR ; POLYDIMETHYLSILOXANE PDMS ; PIEZOELECTRIC MICROPUMP ; DROPLET GENERATION ; CELL-CULTURE ; FLOW
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000448338200002
资助机构	CAS Pioneer Hundred Talents Program ; National Natural Science Foundation of China ; Natural Science Foundation of Jilin Province ; talent project of Jilin Province
内容类型	期刊论文
源URL	[http://ir.ciomp.ac.cn/handle/181722/60486]
专题	中国科学院长春光学精密机械与物理研究所
通讯作者	Wu, Wenming
作者单位	Chinese Acad Sci, Changchun Inst Opt Fine Mech & Phys, State Key Lab Appl Opt, Changchun 130033, Jilin, Peoples R China
推荐引用方式 GB/T 7714	Wu, Wenming. A pressure-driven gas-diffusion/permeation micropump for self-activated sample transport in an extreme micro-environment[J]. ANALYST,2018,143(20):4819-4835.
APA	Wu, Wenming.(2018).A pressure-driven gas-diffusion/permeation micropump for self-activated sample transport in an extreme micro-environment.ANALYST,143(20),4819-4835.
MLA	Wu, Wenming."A pressure-driven gas-diffusion/permeation micropump for self-activated sample transport in an extreme micro-environment".ANALYST 143.20(2018):4819-4835.