Alterations in resting-state functional connectivity of the default mode network in amnestic mild cognitive impairment: an fMRI study

doi:10.1186/s12880-017-0221-9

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	Alterations in resting-state functional connectivity of the default mode network in amnestic mild cognitive impairment: an fMRI study
	Li, MY; Zhou, WJ; Xia, R; Xiong, ZY; Zheng, YH; Zheng, GH; Liang SX(梁胜祥); Chen, LD; Tao, J; Liang, SX
刊名	BMC MEDICAL IMAGING
	2017
卷号	17 页码:48
关键词	Amnestic mild cognitive impairment Default mode network Functional magnetic resonance imaging Functional connectivity Independent component analysis
ISSN号	1471-2342
DOI	10.1186/s12880-017-0221-9
文献子类	Article
英文摘要	Background: Amnestic mild cognitive impairment (aMCI) is characterized by cognitive functional decline, especially in memory. Resting-state functional magnetic resonance imaging (fMRI) has been widely used in neuroimaging studies that explore alterations between patients and normal individuals to elucidate the pathological mechanisms of different diseases. The current study was performed to investigate alterations in the functional connectivity of the default mode network (DMN) in aMCI patients compared to healthy elderly controls, as well as further define the association between neurological alterations and memory function. Methods: Twenty-five aMCI patients and 25 healthy individuals were recruited and underwent both fMRI and neuropsychological examinations. fMRI data was analyzed by independent component analysis. Results: Compared to healthy individuals, aMCI patients exhibited a significant increase in functional connectivity between the DMN and right-middle and right-superior frontal gyri, left-middle occipital gyrus, and left-middle temporal gyrus, but reduced functional connectivity between the DMN and left-middle and left-inferior frontal gyri and left insula. These alterations were found to be associated with reduced memory function. Conclusions: aMCI patients exhibited abnormal functional connectivity between the DMN and certain brain regions which is associated with changes in memory function associated with aMCI.
WOS关键词	ALZHEIMERS-DISEASE ; HUMAN BRAIN ; OLDER-ADULTS ; MEMORY ; INDIVIDUALS ; DEMENTIA ; MCI
WOS研究方向	Radiology, Nuclear Medicine & Medical Imaging
语种	英语
WOS记录号	WOS:000407950600001
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/285255]
专题	高能物理研究所_核技术应用研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Li, MY,Zhou, WJ,Xia, R,et al. Alterations in resting-state functional connectivity of the default mode network in amnestic mild cognitive impairment: an fMRI study[J]. BMC MEDICAL IMAGING,2017,17:48.
APA	Li, MY.,Zhou, WJ.,Xia, R.,Xiong, ZY.,Zheng, YH.,...&Wang, Q.(2017).Alterations in resting-state functional connectivity of the default mode network in amnestic mild cognitive impairment: an fMRI study.BMC MEDICAL IMAGING,17,48.
MLA	Li, MY,et al."Alterations in resting-state functional connectivity of the default mode network in amnestic mild cognitive impairment: an fMRI study".BMC MEDICAL IMAGING 17(2017):48.