Long-term acupuncture treatment has a multi-targeting regulation on multiple brain regions in rats with Alzheimer's disease: a positron emission tomography study

doi:10.4103/1673-5374.211197

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	Long-term acupuncture treatment has a multi-targeting regulation on multiple brain regions in rats with Alzheimer's disease: a positron emission tomography study
	Qu, SS; Zhong, Z; Lai, XS; Steiner, GZ; Dan BC(单保慈); Shan, BC; Tang, CZ; Huang, Y; Zhang, GF; Cai, XW
刊名	NEURAL REGENERATION RESEARCH中国神经再生研究
	2017
卷号	12 期号:7 页码:1159-1165
关键词	nerve regeneration neurodegeneration acupuncture Zusanli (ST36) Alzheimer's disease long-term treatment positron emission tomography rat mechanism targeting effect compensation multi-target regulation neural regeneration
ISSN号	1673-5374
DOI	10.4103/1673-5374.211197
文献子类	Article
英文摘要	The acute effect of acupuncture on Alzheimer's disease, i.e., on brain activation during treatment, has been reported. However, the effect of long-term acupuncture on brain activation in Alzheimer's disease is unclear. Therefore, in this study, we performed long-term needling at Zusanli (ST36) or a sham point (1.5 mm lateral to ST36) in a rat Alzheimer's disease model, for 30 minutes, once per day, for 30 days. The rats underwent 1 F-fluorodeoxyglucose positron emission tomography scanning. Positron emission tomography images were processed with SPM2. The brain areas activated after needling at ST36 included the left hippocampus, the left orbital cortex, the left infralimbic cortex, the left olfactory cortex, the left cerebellum and the left pons. In the sham-point group, the activated regions were similar to those in the ST36 group. However, the ST36 group showed greater activation in the cerebellum and pons than the sham-point group. These findings suggest that long-term acupuncture treatment has targeted regulatory effects on multiple brain regions in rats with Alzheimer's disease.
电子版国际标准刊号	1876-7958
WOS关键词	METABOLISM
WOS研究方向	Cell Biology ; Neurosciences & Neurology
语种	英语
CSCD记录号	CSCD:6045748
WOS记录号	WOS:000407199500026
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/285249]
专题	高能物理研究所_核技术应用研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Qu, SS,Zhong, Z,Lai, XS,et al. Long-term acupuncture treatment has a multi-targeting regulation on multiple brain regions in rats with Alzheimer's disease: a positron emission tomography study[J]. NEURAL REGENERATION RESEARCH中国神经再生研究,2017,12(7):1159-1165.
APA	Qu, SS.,Zhong, Z.,Lai, XS.,Steiner, GZ.,单保慈.,...&Chen, JQ.(2017).Long-term acupuncture treatment has a multi-targeting regulation on multiple brain regions in rats with Alzheimer's disease: a positron emission tomography study.NEURAL REGENERATION RESEARCH中国神经再生研究,12(7),1159-1165.
MLA	Qu, SS,et al."Long-term acupuncture treatment has a multi-targeting regulation on multiple brain regions in rats with Alzheimer's disease: a positron emission tomography study".NEURAL REGENERATION RESEARCH中国神经再生研究 12.7(2017):1159-1165.