Celastrol Protects From Cholestatic Liver Injury Through Modulation of SIRT1-FXR Signaling

doi:10.1074/mcp.RA118.000817

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Celastrol Protects From Cholestatic Liver Injury Through Modulation of SIRT1-FXR Signaling
	Zhao, Qi1,2 ; Liu, Fang 1; Cheng, Yan 1; Xiao, Xue-Rong 1; Hu, Dan-Dan 1; Tang, Ying-Mei 3; Bao, Wei-Min 4; Yang, Jin-Hui 3; Jiang, Tao 3; Hu, Jia-Peng 5
刊名	MOLECULAR & CELLULAR PROTEOMICS
	2019-03-01
卷号	18 期号:3 页码:520-533
ISSN号	1535-9476
DOI	10.1074/mcp.RA118.000817
通讯作者	Tang, Ying-Mei(tangyingmei_med@163.com) ; Li, Fei(lifeib@mail.kib.ac.cn)
英文摘要	Celastrol, derived from the roots of the Tripterygium Wilfordi, shows a striking effect on obesity. In the present study, the role of celastrol in cholestasis was investigated using metabolomics and transcriptomics. Celastrol treatment significantly alleviated cholestatic liver injury in mice induced by alpha-naphthyl isothiocyanate (ANIT) and thioacetamide (TAA). Celastrol was found to activate sirtuin 1 (SIRT1), increase farnesoid X receptor (FXR) signaling and inhibit nuclear factor-kappa B and P53 signaling. The protective role of celastrol in cholestatic liver injury was diminished in mice on co-administration of SIRT1 inhibitors. Further, the effects of celastrol on cholestatic liver injury were dramatically decreased in Fxr-null mice, suggesting that the SIRT1-FXR signaling pathway mediates the protective effects of celastrol. These observations demonstrated a novel role for celastrol in protecting against cholestatic liver injury through modulation of the SIRT1 and FXR.
WOS研究方向	Biochemistry & Molecular Biology
语种	英语
WOS记录号	WOS:000467885100010
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/67577]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Tang, Ying-Mei; Li, Fei
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Kunming Med Univ, Affiliated Hosp 2, Yunnan Res Ctr Liver Dis, Dept Gastroenterol, Kunming 650033, Yunnan, Peoples R China 4.Yunnan Prov 1st Peoples Hosp, Dept Gen Surg, Kunming 650032, Yunnan, Peoples R China 5.Kunming Med Univ, Affiliated Hosp 2, Clin Lab, Kunming 650033, Yunnan, Peoples R China 6.NCI, Lab Metab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA 7.Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Qi,Liu, Fang,Cheng, Yan,et al. Celastrol Protects From Cholestatic Liver Injury Through Modulation of SIRT1-FXR Signaling[J]. MOLECULAR & CELLULAR PROTEOMICS,2019,18(3):520-533.
APA	Zhao, Qi.,Liu, Fang.,Cheng, Yan.,Xiao, Xue-Rong.,Hu, Dan-Dan.,...&Li, Fei.(2019).Celastrol Protects From Cholestatic Liver Injury Through Modulation of SIRT1-FXR Signaling.MOLECULAR & CELLULAR PROTEOMICS,18(3),520-533.
MLA	Zhao, Qi,et al."Celastrol Protects From Cholestatic Liver Injury Through Modulation of SIRT1-FXR Signaling".MOLECULAR & CELLULAR PROTEOMICS 18.3(2019):520-533.