Dayaolingzhiols A-E, AchE inhibitory meroterpenoids from Ganoderma lucidum

doi:10.1016/j.tet.2019.04.022

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Dayaolingzhiols A-E, AchE inhibitory meroterpenoids from Ganoderma lucidum
	Luo, Qi2,3 ; Yang, Zhu-Liang2 ; Cheng, Yong-Xian 1
刊名	TETRAHEDRON
	2019-05-17
卷号	75 期号:20 页码:2910-2915
关键词	Ganoderma lucidum Meroterpenoids Dayaolingzhiols A-E AChE inhibitory activity
ISSN号	0040-4020
DOI	10.1016/j.tet.2019.04.022
通讯作者	Cheng, Yong-Xian(yxcheng@szu.edu.cn)
英文摘要	Ganoderma mushrooms are widely used as effective medicines for treating and preventing chronic diseases. In this study, five new meroterpenoids, dayaolingzhiols A (1) and B (2) featuring a 6/6/6 ring system, dayaolingzhiols C-E (3-5) harboring a gamma-lactone motif, along with eight known ones (6-13), were purified from G. lucidum. To clarify their chemical structures, spectroscopic and ECD and OR computational methods were used. In addition, the inhibition of all the new meroterpenoids against AChE was evaluated, disclosing that (+)-4 and (+/-) 5 possess potent AChE inhibitory activities with respective IC50 values of 8.52 +/- 1.90 mu M and 7.37 +/- 0.52 mu M. (C) 2019 Published by Elsevier Ltd.
WOS研究方向	Chemistry
语种	英语
WOS记录号	WOS:000468718400007
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/67509]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Cheng, Yong-Xian
作者单位	1.Shenzhen Univ, Sch Pharmaceut Sci, Hlth Sci Ctr, Shenzhen 518060, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Key Lab Plant Divers & Biogeog East Asia, Kunming 650201, Yunnan, Peoples R China 3.Univ Tokyo, Biotechnol Res Ctr, Bunkyo Ku, 1-1-1 Yayoi, Tokyo 1138657, Japan
推荐引用方式 GB/T 7714	Luo, Qi,Yang, Zhu-Liang,Cheng, Yong-Xian. Dayaolingzhiols A-E, AchE inhibitory meroterpenoids from Ganoderma lucidum[J]. TETRAHEDRON,2019,75(20):2910-2915.
APA	Luo, Qi,Yang, Zhu-Liang,&Cheng, Yong-Xian.(2019).Dayaolingzhiols A-E, AchE inhibitory meroterpenoids from Ganoderma lucidum.TETRAHEDRON,75(20),2910-2915.
MLA	Luo, Qi,et al."Dayaolingzhiols A-E, AchE inhibitory meroterpenoids from Ganoderma lucidum".TETRAHEDRON 75.20(2019):2910-2915.