| Impairment of gill structural integrity by manganese deficiency or excess related to induction of oxidative damage, apoptosis and dysfunction of the physical barrier as regulated by NF-kappa B, caspase and Nrf2 signaling in fish | |
| Jiang, Wei-Dan1,2,3; Tang, Ren-Jun1; Liu, Yang1,2,3; Wu, Pei1,2,3; Kuang, Sheng-Yao4; Jiang, Jun1,2,3; Tang, Ling4; Tang, Wu-Neng4; Zhang, Yong-An5; Zhou, Xiao-Qiu1,2,3 | |
| 刊名 | FISH & SHELLFISH IMMUNOLOGY
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| 2017-11-01 | |
| 卷号 | 70期号:1页码:280-292 |
| 关键词 | Manganese Cytoldne Tight junction Gill Antioxidant Nrf2 |
| ISSN号 | 1050-4648 |
| DOI | 10.1016/j.fsi.2017.09.022 |
| 英文摘要 | This study is for the first time to explore the possible effects of dietary manganese (Mn) on structural integrity and the related signaling in the gills of fish. Grass carp (Ctenopharyngodon idella) were fed with six diets containing graded levels of Mn [3.65-27.86 mg Mn/kg diet] for 8 weeks. The results firstly demonstrated that Mn deficiency aggravated inflammation indicated by up-regulation of pro inflammatory cytokines (tumour necrosis factor alpha, interleukin 8, and interleukin 1 beta mRNA levels) and down-regulation of anti-inflammatory cytokines (interleukin 10, transforming growth factor-beta 1) mRNA levels, which might be partially related to the up-regulation of nuclear factor kappa B (NF-kappa B p65) and down-regulation of nuclear inhibitor factor kappa B alpha (i kappa B alpha) mRNA levels in the gills of fish. Meanwhile, Mn deficiency caused DNA fragmentation, which might be partially associated with the up-regulation of the apoptosis signaling (caspase-3, caspase-8 and caspase-9) in the gills of fish. Furthermore, Mn deficiency caused apoptosis might be partly related to the increases of oxidative damage that indicated by increases of lipid peroxidation and protein oxidation, and decreases of antioxidant enzyme activities [included Mn superoxide dismutase (MnSOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione-S-transferase (GST)]. However, Mn deficiency only down-regulated MnSOD and GST mRNA levels, which might be partially related to the up-regulation of NF-E2-related factor-2 (Nrf2) inhibitor (Keap1), and only down-regulated the gene expression of claudin-b and claudin-15 to disrupt the TJ in the gills of fish. Excessive Mn led to negative effects on partial parameters studied in the gills of fish. The optimal levels of Mn based on protecting against ROS, MDA and PC in the gills of grass carp were 17.04, 16.86 and 21.20 mg/kg diet, respectively. Collectively, Mn deficiency or excess could cause inflammation, apoptosis, antioxidant system disruption and change tight junction protein (claudin-b and claudin-15.) transcription abundances, which might be partially related to the NF-kappa B p65, caspase-(3,8,9) and Nrf2 signaling, in the gills of fish. (C) 2017 Published by Elsevier Ltd. |
| 资助项目 | National Basic Research Program of China (973 Program)[2014CB138600] ; National Natural Science Foundation of China[31672664] ; National Department Public Benefit Research Foundation (Agriculture) of China[201003020] ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture) ; Earmarked Fund for China Agriculture Research System[CARS-45] ; Science and Technology Support Program of Sichuan Province of China[2014NZ0003] ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China[2012NC0007] ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China[2013NC0045] ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China[2015CC0011] ; Natural Science Foundation for Young Scientists of Sichuan Province[2014JQ0007] ; Foundation of Sichuan Youth Science and Technology Innovation Research Team[2017TD0002] |
| WOS关键词 | CARP CTENOPHARYNGODON-IDELLA ; TIGHT JUNCTION PROTEINS ; MESSENGER-RNA EXPRESSION ; MUCOSAL IMMUNE-SYSTEM ; ANTIOXIDANT CAPACITY ; TRANSCRIPT ABUNDANCE ; DIETARY MANGANESE ; GENE-EXPRESSION ; AEROMONAS-SALMONICIDA ; VALINE DEFICIENCY |
| WOS研究方向 | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| 语种 | 英语 |
| 出版者 | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
| WOS记录号 | WOS:000416186800029 |
| 资助机构 | National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; 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| 内容类型 | 期刊论文 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/30214]  |
| 专题 | 水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文 |
| 通讯作者 | Zhou, Xiao-Qiu; Feng, Lin |
| 作者单位 | 1.Sichuan Agr Univ, Anim Nutr Inst, Chengdu 611130, Sichuan, Peoples R China 2.Sichuan Agr Univ, Fish Nutr & Safety Prod Sichuan Univ Key Lab, Chengdu 611130, Sichuan, Peoples R China 3.Sichuan Agr Univ, Key Lab Anim Dis Resistance Nutr, China Minist Educ, Chengdu 611130, Sichuan, Peoples R China 4.Sichuan Acad Anim Sci, Anim Nutr Inst, Chengdu 610066, Sichuan, Peoples R China 5.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Wei-Dan,Tang, Ren-Jun,Liu, Yang,et al. Impairment of gill structural integrity by manganese deficiency or excess related to induction of oxidative damage, apoptosis and dysfunction of the physical barrier as regulated by NF-kappa B, caspase and Nrf2 signaling in fish[J]. FISH & SHELLFISH IMMUNOLOGY,2017,70(1):280-292. |
| APA | Jiang, Wei-Dan.,Tang, Ren-Jun.,Liu, Yang.,Wu, Pei.,Kuang, Sheng-Yao.,...&Feng, Lin.(2017).Impairment of gill structural integrity by manganese deficiency or excess related to induction of oxidative damage, apoptosis and dysfunction of the physical barrier as regulated by NF-kappa B, caspase and Nrf2 signaling in fish.FISH & SHELLFISH IMMUNOLOGY,70(1),280-292. |
| MLA | Jiang, Wei-Dan,et al."Impairment of gill structural integrity by manganese deficiency or excess related to induction of oxidative damage, apoptosis and dysfunction of the physical barrier as regulated by NF-kappa B, caspase and Nrf2 signaling in fish".FISH & SHELLFISH IMMUNOLOGY 70.1(2017):280-292. |
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