Comparative study of the immunoprotective effect of two DNA vaccines against grass carp reovirus | |
Chen, Dan-Dan1,2,3; Yao, Yuan-Yuan1,4; Cui, Zheng-Wei1,4; Zhang, Xiang-Yang1,4; Peng, Kai-Song5; Guo, Xia6; Wang, Biao1; Zhou, Yuan-Yuan1,4; Li, Shun1,3; Wu, Nan1,3 | |
刊名 | FISH & SHELLFISH IMMUNOLOGY |
2018-04-01 | |
卷号 | 75期号:1页码:66-73 |
关键词 | Grass carp reovirus DNA vaccine Antibodies Immunoprotection Immune response |
ISSN号 | 1050-4648 |
DOI | 10.1016/j.fsi.2018.01.047 |
英文摘要 | Grass carp reovirus II (GCRV II) causes severe hemorrhagic disease with high mortality in grass carp, Cyenopharyngodon idellus. DNA vaccination has been proven to be a very effective method in conferring protection against fish viruses. However, DNA vaccines for GCRV II have not yet been conducted on grass carp. In the current work, we vaccinated grass carp with a DNA vaccine consisting of the segment 6 (pC-S6; encoding VP4) or 10 (pC-S10; encoding NS38) of GCRV II and comparatively analyzed the immune responses induced by these two vaccines. The protective efficacy of pC-S6 and pC-S10, in terms of relative percentage survival (RPS), was 59.9% and 23.1% respectively. This suggests that pC-S6 and pC-S10 DNA vaccines could increase the survival rate of grass carp against GCRV, albeit with variations in immunoprotective effect. Immunological analyses indicated the following. First, post-vaccination (pv), both pC-S6 and pC-S10 up-regulated the expression of interferon (IFN-1), Mx1, IL-1 beta, and TNF-alpha. However, CD4 and CD8 alpha were up-regulated in the case of pC-S6 but not pC-S10. Second, comparing non-vaccinated and pC-S10-vaccinated fish, the T cell response related genes, such as CD4, CD8 alpha, and GATA3, were elevated in pC-S6-vaccinated fish at 48 h post-challenge (pc). Third, pC-S6 and pC-S10 induced similar patterns of specific antibody response pv. However, only anti-VP4 IgM in the sera of surviving fish infected with GCRV was significantly increased pc compared with that pre-challenge. Taken together, these results indicate that pC-S6 promotes both innate (IFN-1 and Mx1 induction) and adaptive CT cell and specific antibody response) immunity pv and that the induction of a memory state promptly primes the immune response upon later encounters with the virus, whereas pC-S10 only induces the type I IFN-related response pv and a lower inflammatory response pc. |
资助项目 | National Basic Research Program of China[2014CB138601] ; CAS Major Scientific and Technological Project[XDA08010207] |
WOS关键词 | HEMATOPOIETIC NECROSIS VIRUS ; HEMORRHAGIC SEPTICEMIA VIRUS ; COMPLETE GENOME SEQUENCE ; SALMON SALMO-SALAR ; RAINBOW-TROUT ; PROTECTIVE IMMUNITY ; ONCORHYNCHUS-MYKISS ; CARBON NANOTUBES ; YERSINIA-RUCKERI ; TELEOST FISH |
WOS研究方向 | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
语种 | 英语 |
出版者 | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
WOS记录号 | WOS:000428824900009 |
资助机构 | National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project ; CAS Major Scientific and Technological Project |
内容类型 | 期刊论文 |
源URL | [http://ir.ihb.ac.cn/handle/342005/29573] |
专题 | 水生生物研究所_其他_期刊论文 |
通讯作者 | Zhang, Yong-An |
作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Hubei, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 3.Minist Agr, Key Lab Aquaculture Dis Control, Wuhan, Hubei, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China 5.Anhui Agr Univ, Coll Anim Sci & Technol, Hefei, Anhui, Peoples R China 6.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan, Hubei, Peoples R China |
推荐引用方式 GB/T 7714 | Chen, Dan-Dan,Yao, Yuan-Yuan,Cui, Zheng-Wei,et al. Comparative study of the immunoprotective effect of two DNA vaccines against grass carp reovirus[J]. FISH & SHELLFISH IMMUNOLOGY,2018,75(1):66-73. |
APA | Chen, Dan-Dan.,Yao, Yuan-Yuan.,Cui, Zheng-Wei.,Zhang, Xiang-Yang.,Peng, Kai-Song.,...&Zhang, Yong-An.(2018).Comparative study of the immunoprotective effect of two DNA vaccines against grass carp reovirus.FISH & SHELLFISH IMMUNOLOGY,75(1),66-73. |
MLA | Chen, Dan-Dan,et al."Comparative study of the immunoprotective effect of two DNA vaccines against grass carp reovirus".FISH & SHELLFISH IMMUNOLOGY 75.1(2018):66-73. |
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