A photostable fluorescent probe for long-time imagining of lysosome in cell and nematode

doi:10.1016/j.talanta.2018.06.001

CORC > 化学研究所 > 中国科学院化学研究所 > 分子动态与稳态结构实验室

	A photostable fluorescent probe for long-time imagining of lysosome in cell and nematode
	Li, Changjian 1,2; Wang, Yueqi 1,2; Huang, Saipeng 3; Zhang, Xiaojie 1; Kang, Xiaoxuan 1; Sun, Yanchi 4; Hu, Ziyuan 4; Han, Lu 4; Du, Libo 1; Liu, Yang 1
刊名	TALANTA
	2018-10-01
卷号	188 页码:316-324
关键词	Lysosome Imaging Photostability Long-term Imagining Fluorescence 1 8-naphthalimides
ISSN号	0039-9140
DOI	10.1016/j.talanta.2018.06.001
英文摘要	Lysosome fluorescent imaging has been widely used in the field of biological staining and diagnostics, which plays a key role in understanding intracellular metabolism and various physiological processes. However, for most currently used small-molecule lysotrackers, the photostability is often unsatisfactory when used for long-term and real-time visualization of lysosomal dynamics. Herein, we reported a new lysosome-targetable photostable fluorescent probe (i.e. MPL-NPA), and results showed that MPL-NAP possesses superior photostability, appreciable tolerance to pH change, low cytotoxicity and high lysosome targeting ability. These findings confirm that MPL-NAP is a well-suited imaging agent for targeting lysosome and enables long-term and real-time monitor of lysosome morphological changes under physiological processes.
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000440958700042
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/41945]
专题	化学研究所_分子动态与稳态结构实验室
通讯作者	Du, Libo; Liu, Yang
作者单位	1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Northwest Univ, Sch Chem Engn, Xian 710075, Shaanxi, Peoples R China 4.Beijing Inst Graph Commun, Beijing Engn Res Ctr Printed Elect, Beijing 102600, Peoples R China
推荐引用方式 GB/T 7714	Li, Changjian,Wang, Yueqi,Huang, Saipeng,et al. A photostable fluorescent probe for long-time imagining of lysosome in cell and nematode[J]. TALANTA,2018,188:316-324.
APA	Li, Changjian.,Wang, Yueqi.,Huang, Saipeng.,Zhang, Xiaojie.,Kang, Xiaoxuan.,...&Liu, Yang.(2018).A photostable fluorescent probe for long-time imagining of lysosome in cell and nematode.TALANTA,188,316-324.
MLA	Li, Changjian,et al."A photostable fluorescent probe for long-time imagining of lysosome in cell and nematode".TALANTA 188(2018):316-324.