Syntheses and physical characterization of new aliphatic triblock poly(L-lactide-b-butylene succinate-b-L-lactide)s bearing soft and hard biodegradable building blocks

doi:10.1021/bm034235p

CORC > 化学研究所 > 中国科学院化学研究所

	Syntheses and physical characterization of new aliphatic triblock poly(L-lactide-b-butylene succinate-b-L-lactide)s bearing soft and hard biodegradable building blocks
	Ba, CY; Yang, J; Hao, QH; Liu, XY; Cao, A
刊名	BIOMACROMOLECULES
	2003-11-01
卷号	4 期号:6 页码:1827-1834
ISSN号	1525-7797
DOI	10.1021/bm034235p
英文摘要	This study presents chemical syntheses and physical characterization of a new aliphatic poly(L-lactide-b-butylene succinate-b-L-lactide) triblock copolyester with soft and hard biodegradable building blocks. First, poly(butylene succinate) (PBS) prepolymers terminated with hydroxyl functional groups were synthesized through melt polycondensation from succinic acid and 1,4-butanediol. Further, a series of new PLLA-b-PBS-b-PLLA triblock copolyesters bearing various average PLLA block lengths were prepared via ring opening polymerization Of L-lactide with the synthesized hydroxyl capped PBS prepolymer ((M) over bar (n) = 4.9 KDa) and stannous octanoate as the macroinitiator and catalyst, respectively. By means of GPC, NMR, FTIR, DSC, TGA, and wide-angle X-ray diffractometer (WAXD), the macromolecular structures and physical properties were intensively studied for these synthesized PBS prepolymer and PLLA-b-PBS-b-PLLA triblock copolyesters. C-13 NMR and GPC experimental results confirmed the formation of sequential block structures without any detectable transesterification under the present experimental conditions, and the molecular weights of triblock copolyesters could be readily regulated by adjusting the feeding molar ratio of L-lactide monomer to the PBS macroinitiator. DSC measurements showed all single glass transitions, and their glass transition temperatures were found to be between those of PLLA and PBS, depending on the lengths of PLLA blocks. It was noteworthy that the segmental flexibilities of the hard PLLA blocks were found to be remarkably enhanced by the more flexible PBS block partner, and the PBS and PLLA building blocks were well mixed in the amorphous regions. Results of TGA analyses indicated that thermal degradation and stabilities of the PLLA blocks strongly depended on the average PLLA block lengths of triblock copolyesters. In addition, FTIR and WAXD results showed the coexistence of the assemblied PLLA and PBS crystal structures when the average PLLA block length became larger than 7.8. These results may be beneficial for this new biodegradable aliphatic triblock copolyester to be applied as a potential biomaterial.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000186729700048
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/80327]
专题	中国科学院化学研究所
通讯作者	Cao, A
作者单位	Chinese Acad Sci, Shanghai Inst Organ Chem, Polymer Mat Lab, Shanghai 200032, Peoples R China
推荐引用方式 GB/T 7714	Ba, CY,Yang, J,Hao, QH,et al. Syntheses and physical characterization of new aliphatic triblock poly(L-lactide-b-butylene succinate-b-L-lactide)s bearing soft and hard biodegradable building blocks[J]. BIOMACROMOLECULES,2003,4(6):1827-1834.
APA	Ba, CY,Yang, J,Hao, QH,Liu, XY,&Cao, A.(2003).Syntheses and physical characterization of new aliphatic triblock poly(L-lactide-b-butylene succinate-b-L-lactide)s bearing soft and hard biodegradable building blocks.BIOMACROMOLECULES,4(6),1827-1834.
MLA	Ba, CY,et al."Syntheses and physical characterization of new aliphatic triblock poly(L-lactide-b-butylene succinate-b-L-lactide)s bearing soft and hard biodegradable building blocks".BIOMACROMOLECULES 4.6(2003):1827-1834.