Highly enantioselective biotransformations of 2-aryl-4-pentenenitriles, a novel chemoenzymatic approach to (R)-(-)-baclofen

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	Highly enantioselective biotransformations of 2-aryl-4-pentenenitriles, a novel chemoenzymatic approach to (R)-(-)-baclofen
	Wang, MX; Zhao, SM
刊名	TETRAHEDRON LETTERS
	2002-09-09
卷号	43 期号:37 页码:6617-6620
关键词	Biotransformations Nitrile Hydratase Amidase Chemoenzymatic Synthesis (r)-(-)-baclofen
ISSN号	0040-4039
英文摘要	Catalyzed by Rhodococcus sp. AJ270 microbial cells under mild conditions, a range of racemic 2-aryl-4-pentenenitriles 1 underwent effective hydrolysis to afford excellent yields of enantiomerically pure (R)-(-)-2-aryl-4-pentenamides 2 and (S)-(+)-2-aryl-4-pentenoic acids 3 in most cases. The application of this biotransformation has been shown by a two-step synthesis of (R)-(-)-baclcfen. (C) 2002 Elsevier Science Ltd. All rights reserved.
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000177659700031
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/78995]
专题	中国科学院化学研究所
通讯作者	Wang, MX
作者单位	Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Wang, MX,Zhao, SM. Highly enantioselective biotransformations of 2-aryl-4-pentenenitriles, a novel chemoenzymatic approach to (R)-(-)-baclofen[J]. TETRAHEDRON LETTERS,2002,43(37):6617-6620.
APA	Wang, MX,&Zhao, SM.(2002).Highly enantioselective biotransformations of 2-aryl-4-pentenenitriles, a novel chemoenzymatic approach to (R)-(-)-baclofen.TETRAHEDRON LETTERS,43(37),6617-6620.
MLA	Wang, MX,et al."Highly enantioselective biotransformations of 2-aryl-4-pentenenitriles, a novel chemoenzymatic approach to (R)-(-)-baclofen".TETRAHEDRON LETTERS 43.37(2002):6617-6620.