Effect of structural modification on photodynamic activity of hypocrellins

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	Effect of structural modification on photodynamic activity of hypocrellins
	Ma, JH; Zhao, JQ; Jiang, LJ
刊名	PHOTOCHEMISTRY AND PHOTOBIOLOGY
	2001-08-01
卷号	74 期号:2 页码:143-148
ISSN号	0031-8655
英文摘要	Aluminum ion complexed 5,8-di-Br-hypocrellin B is a new water-soluble perylenequinonoid derivative with enhanced absorption over hypocrellin B (HB) in the phototherapeutic window (600-900 nm). Electron paramagnetic resonance and 9,10-diphenyl-anthracene bleaching methods were used to investigate the photosensitizing activity of [Al-2(5,8-di-Br-HB)Cl-4], in the presence of oxygen. Singlet oxygen, superoxide anion radical and hydroxyl radical can be generated by [Al-2(5,8-di-Br-HB)Cl-4](n) photosensitization. Singlet oxygen (O-1(2)) is formed via energy transfer from triplet-state [Al-2(5,8-di-Br-HB)Cl-4](n), to ground-state molecular oxygen. O-1(2) participates in the generation of a portion of superoxide anion radical (O-2(.-)). Besides superoxide anion radical (O-2(.-)) may originate from the electron transfer between the triplet-state [Al-2(5,8-di-Br-HB)Cl-4](n) and the ground-state molecular oxygen. (OH)-O-. is formed through the Fenton-Haber-Weiss reaction and the decomposition of DMPO-O-1(2) adduct. Compared with HB [Al-2(5,8-di-Br-HB)Cl-4](n) primarily remains and enhances the generation efficiency of superoxide anion radical and hydroxyl radical but that of singlet oxygen decreases.
语种	英语
出版者	AMER SOC PHOTOBIOLOGY
WOS记录号	WOS:000170619600005
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/76631]
专题	中国科学院化学研究所
通讯作者	Zhao, JQ
作者单位	Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Ma, JH,Zhao, JQ,Jiang, LJ. Effect of structural modification on photodynamic activity of hypocrellins[J]. PHOTOCHEMISTRY AND PHOTOBIOLOGY,2001,74(2):143-148.
APA	Ma, JH,Zhao, JQ,&Jiang, LJ.(2001).Effect of structural modification on photodynamic activity of hypocrellins.PHOTOCHEMISTRY AND PHOTOBIOLOGY,74(2),143-148.
MLA	Ma, JH,et al."Effect of structural modification on photodynamic activity of hypocrellins".PHOTOCHEMISTRY AND PHOTOBIOLOGY 74.2(2001):143-148.