Design Guidelines For Conjugated Polymers With Light-Activated Anticancer Activity

doi:10.1002/adfm.201100840

CORC > 化学研究所 > 中国科学院化学研究所

	Design Guidelines For Conjugated Polymers With Light-Activated Anticancer Activity
	Xing, Chengfen 1; Liu, Libing 1; Tang, Hongwei 1; Feng, Xuli 1; Yang, Qiong 1; Wang, Shu 1; Bazan, Guillermo C.2,3
刊名	ADVANCED FUNCTIONAL MATERIALS
	2011-11-08
卷号	21 期号:21 页码:4058-4067
ISSN号	1616-301X
DOI	10.1002/adfm.201100840
英文摘要	Multifunctional materials that simultaneously provide therapeutic action and image the results provide new strategies for the treatment of various diseases. Here, it is shown that water soluble conjugated polymers with a molecular design centered on the polythiophene-porphyrin dyad are effective for killing neighboring cells. Following photoexcitation, energy is efficiently transferred from the polythiophene backbone to the porphyrin units, which readily produce singlet oxygen ((1)O(2)) that is toxic for the cells. Due to the light-harvesting ability of the electronically delocalized backbone and the efficient energy transfer amongst optical partners, the polythiophene-porphyrin dyad shows a higher (1)O(2) generation efficiency than a small molecule analog. The fluorescent properties of these polymers can also serve to distinguish amongst living and dead cells. Polymers can be designed with folic acid grafted onto the polymer side chain that can specifically kill folate receptor-overexpressed cells, thereby providing an important demonstration of anticancer specificity through molecular design.
语种	英语
出版者	WILEY-BLACKWELL
WOS记录号	WOS:000297096900007
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/73151]
专题	中国科学院化学研究所
通讯作者	Xing, Chengfen
作者单位	1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Organ Solids, Inst Chem, Beijing 100190, Peoples R China 2.Univ Calif Santa Barbara, Ctr Polymers & Organ Solids, Dept Chem & Biochem, Santa Barbara, CA 93106 USA 3.Univ Calif Santa Barbara, Ctr Polymers & Organ Solids, Dept Mat, Santa Barbara, CA 93106 USA
推荐引用方式 GB/T 7714	Xing, Chengfen,Liu, Libing,Tang, Hongwei,et al. Design Guidelines For Conjugated Polymers With Light-Activated Anticancer Activity[J]. ADVANCED FUNCTIONAL MATERIALS,2011,21(21):4058-4067.
APA	Xing, Chengfen.,Liu, Libing.,Tang, Hongwei.,Feng, Xuli.,Yang, Qiong.,...&Bazan, Guillermo C..(2011).Design Guidelines For Conjugated Polymers With Light-Activated Anticancer Activity.ADVANCED FUNCTIONAL MATERIALS,21(21),4058-4067.
MLA	Xing, Chengfen,et al."Design Guidelines For Conjugated Polymers With Light-Activated Anticancer Activity".ADVANCED FUNCTIONAL MATERIALS 21.21(2011):4058-4067.