Thermoresponsive Gene Carriers Based on Polyethylenimine-graft-Poly[oligo(ethylene glycol) methacrylate]

doi:10.1002/mabi.201100094

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	Thermoresponsive Gene Carriers Based on Polyethylenimine-graft-Poly[oligo(ethylene glycol) methacrylate]
	Zhang, Rui 1; Wang, Yang 1; Du, Fu-Sheng 1; Wang, Ying-Li 2; Tan, Ying-Xia 2; Ji, Shou-Ping 2; Li, Zi-Chen 1
刊名	MACROMOLECULAR BIOSCIENCE
	2011-10-10
卷号	11 期号:10 页码:1393-1406
关键词	Cationic Gene Carriers Hyperthermia Polyethylenimine Poly[Oligo(Ethylene Glycol) Methacrylate] Thermoresponsive
ISSN号	1616-5187
DOI	10.1002/mabi.201100094
英文摘要	A family of thermoresponsive cationic copolymers (TCPs) that contain branched PEI 25 K as the cationic segment and poly(MEO(2)MA-co-OEGMA(475)) as the thermosensitive block (TP) is prepared. The DNA binding capability, physicochemical properties, and biological performance of the TCPs are studied. All of these TCPs can condense DNA to form polyplexes with diameters of 150-300nm and zeta potentials of 7-32mV at N/P ratios between 12 and 36. The length of TP block is a key factor for shielding the positive surface charge of the polyplexes and protecting them against protein adsorption. TCPs with a higher TP content have a lower cytotoxicity while the best transfection performance is achieved by the TCPs with longest TP length, reaching a level of the intact PEI 25 K in the presence of serum.
语种	英语
出版者	WILEY-BLACKWELL
WOS记录号	WOS:000296138500012
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/71465]
专题	中国科学院化学研究所
通讯作者	Du, Fu-Sheng
作者单位	1.Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Polymer Chem & Phys, Minist Educ,Coll Chem & Mol Engn, Beijing 100871, Peoples R China 2.Beijing Inst Transfus Med, Dept Mol Biol, Beijing 100850, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Rui,Wang, Yang,Du, Fu-Sheng,et al. Thermoresponsive Gene Carriers Based on Polyethylenimine-graft-Poly[oligo(ethylene glycol) methacrylate][J]. MACROMOLECULAR BIOSCIENCE,2011,11(10):1393-1406.
APA	Zhang, Rui.,Wang, Yang.,Du, Fu-Sheng.,Wang, Ying-Li.,Tan, Ying-Xia.,...&Li, Zi-Chen.(2011).Thermoresponsive Gene Carriers Based on Polyethylenimine-graft-Poly[oligo(ethylene glycol) methacrylate].MACROMOLECULAR BIOSCIENCE,11(10),1393-1406.
MLA	Zhang, Rui,et al."Thermoresponsive Gene Carriers Based on Polyethylenimine-graft-Poly[oligo(ethylene glycol) methacrylate]".MACROMOLECULAR BIOSCIENCE 11.10(2011):1393-1406.