Supramolecular Hydrogels from Cisplatin-Loaded Block Copolymer Nanoparticles and alpha-Cyclodextrins with a Stepwise Delivery Property

doi:10.1021/bm100889j

CORC > 化学研究所 > 中国科学院化学研究所

	Supramolecular Hydrogels from Cisplatin-Loaded Block Copolymer Nanoparticles and alpha-Cyclodextrins with a Stepwise Delivery Property
	Zhu, Wen ; Li, Yanli 1; Liu, Lixin 1; Chen, Yongming 2; Wang, Chun 3; Xi, Fu 2
刊名	BIOMACROMOLECULES
	2010-11-01
卷号	11 期号:11 页码:3086-3092
ISSN号	1525-7797
DOI	10.1021/bm100889j
英文摘要	A stepwise anticancer drug delivery system based on an injectable supramolecular hydrogel was presented. In this system, poly(ethylene glycol)-b-poly(acrylic acid) (PEG-b-PAA) block copolymer nanoparticles containing cisplatin were released by erosion of the hydrogels and then the cisplatin was released from the nanoparticles by exchanging with chloride ions. By mixing a-cyclodextrins (alpha-CDs) and the PEG-b-PAA micelles with their PAA cores loaded with the cisplatin in water, the novel supramolecular hydrogels were generated by threading alpha-CDs onto the PEG segments and forming physical cross-links of molecular necklaces. The gelation properties could be tuned by changing concentrations of the polymers and cisplatin, their feeds, and by adding PEG homopolymers or Pluronic copolymers as additives. Structures and properties of the supramolecular hydrogels containing cisplatin were studied by wide-angle X-ray diffraction (XRD) and rheology measurements, respectively. The thixotropic effect of the hydrogels and their reversible sol gel transition were confirmed. In vitro hydrogel erosion experiments were conducted and cisplatin release in saline and pure water was quantified. Hydrogel erosion produced discrete nanoparticles from which cisplatin was released completely in saline. In contrast, the hydrogels were eroded into nanoparticles in pure water, but no cisplatin could be released. In vitro cytotoxicity studies showed that the cisplatin-loaded hydrogels inhibited the growth of human bladder carcinoma EJ cells with a similar potency as that of the free cisplatin, whereas the hydrogels without cisplatin showed no cytotoxicity. These results suggested that the cisplatin-coordinated PEG-b-PAA/alpha-CD supramolecular hydrogels hold great potential as an injectable system for sustained delivery of cisplatin in cancer therapy.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000283810900034
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/71213]
专题	中国科学院化学研究所
通讯作者	Liu, Lixin
作者单位	1.Chinese Acad Sci, Grad Univ, Coll Life Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Chem, Lab Polymer Phys & Chem, Beijing 100190, Peoples R China 3.Univ Minnesota, Dept Biomed Engn, Minneapolis, MN 55455 USA
推荐引用方式 GB/T 7714	Zhu, Wen,Li, Yanli,Liu, Lixin,et al. Supramolecular Hydrogels from Cisplatin-Loaded Block Copolymer Nanoparticles and alpha-Cyclodextrins with a Stepwise Delivery Property[J]. BIOMACROMOLECULES,2010,11(11):3086-3092.
APA	Zhu, Wen,Li, Yanli,Liu, Lixin,Chen, Yongming,Wang, Chun,&Xi, Fu.(2010).Supramolecular Hydrogels from Cisplatin-Loaded Block Copolymer Nanoparticles and alpha-Cyclodextrins with a Stepwise Delivery Property.BIOMACROMOLECULES,11(11),3086-3092.
MLA	Zhu, Wen,et al."Supramolecular Hydrogels from Cisplatin-Loaded Block Copolymer Nanoparticles and alpha-Cyclodextrins with a Stepwise Delivery Property".BIOMACROMOLECULES 11.11(2010):3086-3092.