Structure and properties of polysaccharide nanocrystal-doped supramolecular hydrogels based on Cyclodextrin inclusion

doi:10.1016/j.polymer.2010.07.025

CORC > 化学研究所 > 中国科学院化学研究所

	Structure and properties of polysaccharide nanocrystal-doped supramolecular hydrogels based on Cyclodextrin inclusion
	Zhang, Xiaolan 1; Huang, Jin 1,4,5; Chang, Peter R.2; Li, Junli 1; Chen, Yongming 7; Wang, Daxin 3; Yu, Jiahui 4; Chen, Jinghua 6
刊名	POLYMER
	2010-09-03
卷号	51 期号:19 页码:4398-4407
关键词	Supramolecular Hydrogel Cyclodextrin Inclusion Polysaccharide Nanocrystal
ISSN号	0032-3861
DOI	10.1016/j.polymer.2010.07.025
英文摘要	Polysaccharide nanocrystals, such as the rod-like whiskers of cellulose and chitin, and platelet-like starch nanocrystals, were for the first time incorporated into supramolecular hydrogels based on cyclodextrin/polymer inclusion in order to enhance mechanical strength and regulate drug release behavior The structures and properties of the resultant nanocomposite hydrogels were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and rheological testing As expected, the elastic modulus of the nanocomposite hydrogels climbed, owing to the reinforcing function of the polysaccharide nanocrystals The modulus of the cellulose whisker-doped hydrogel was 50 times higher than that of the native hydrogel Furthermore, the presence of polysaccharide nanocrystals increased the stability of the hydrogel framework and inhibited the diffusion of bovine serum albumin, which served as a model protein drug in the nanocomposite hydrogels and showed prominent sustained release profiles Importantly, the incorporation of polysaccharide nanocrystals did not show additional cytotoxicity as comparison with the native hydrogel In addition, the inherited shear-thinning property of the nanocomposite hydrogels contributed to their potential as injectable biomaterials (C) 2010 Elsevier Ltd All rights reserved.
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000281506100015
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/70371]
专题	中国科学院化学研究所
通讯作者	Huang, Jin
作者单位	1.Wuhan Univ Technol, Coll Chem Engn, Wuhan 430070, Peoples R China 2.Agr & Agri Food Canada, Bioprod & Bioproc Natl Sci Program, Saskatoon, SK S7N 0X2, Canada 3.Yangzhou Univ, Subei Peoples Hosp Jiangsu Prov, Yangzhou 225001, Peoples R China 4.E China Normal Univ, Interdisciplinary Sci & Technol Inst Adv Study, Shanghai 200062, Peoples R China 5.S China Univ Technol, State Key Lab Pulp & Paper Engn, Guangzhou 510640, Guangdong, Peoples R China 6.Jiangnan Univ, Sch Med & Pharmaceut, Wuxi 214122, Peoples R China 7.Chinese Acad Sci, Inst Chem, Div Polymer Sci & Mat, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Xiaolan,Huang, Jin,Chang, Peter R.,et al. Structure and properties of polysaccharide nanocrystal-doped supramolecular hydrogels based on Cyclodextrin inclusion[J]. POLYMER,2010,51(19):4398-4407.
APA	Zhang, Xiaolan.,Huang, Jin.,Chang, Peter R..,Li, Junli.,Chen, Yongming.,...&Chen, Jinghua.(2010).Structure and properties of polysaccharide nanocrystal-doped supramolecular hydrogels based on Cyclodextrin inclusion.POLYMER,51(19),4398-4407.
MLA	Zhang, Xiaolan,et al."Structure and properties of polysaccharide nanocrystal-doped supramolecular hydrogels based on Cyclodextrin inclusion".POLYMER 51.19(2010):4398-4407.