Studies on the Protonation Structure of Ofloxacin in Concentrated Sulfuric Acid Solutions | |
Li Hui-Zhen1,2; Liu Shao-Xuan1; Hua Xiao-Hui1; Pan Qing-Hua1; Yang Zhan-Lan1; Gao Xiu-Xiang1; Zhu Xi3; Xu Yi-Zhuang1; Wu Jin-Guang1 | |
刊名 | CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE |
2010-09-10 | |
卷号 | 31期号:9页码:1747-1752 |
关键词 | Ofloxacin Quinolone Nmr Protonation |
ISSN号 | 0251-0790 |
英文摘要 | Systematic NMR spectroscopic investigation on ofloxacin(OFL) in concentrated sulfuric acid solution was carried out via (19)F NMR, (1)H NMR and (13)C NMR experiments. Complete assignment on (19)F NMR, (1)H NMR and (13)C NMR of ofloxacin in sulfuric acid solutions were obtained. The chemical shift of H, F, C, and the J(FC) of OFL molecule in sulfuric acid solutions of different concentrations were found to be very helpful for the identification the protonation structure of OFL molecule. According to the variation of the chemical shift of H, F, C, and the J(FC) of OFL molecule in sulfuric acid solutions of different concentrations, we propose that the N(1), is further protonated in concentrated sulfuric acid solutions. Additionally, a new hydrogen bond (N(1),-H center dot center dot center dot F9) forms and the structure can be stabilized by a five-member ring and the conjugate system is distorted by the five-member ring. As a result, the emission peak, excitation peak in fluorescent spectra and absorption peak in UV spectra of OFL exhibit blue-shifted significantly. In addition, the proposed protonation structure was further supported by spectroscopic behavior of oxygen-fluorine acid and methyl-ofloxacin. |
语种 | 英语 |
出版者 | HIGHER EDUCATION PRESS |
WOS记录号 | WOS:000282379300012 |
内容类型 | 期刊论文 |
源URL | [http://ir.iccas.ac.cn/handle/121111/70275] |
专题 | 中国科学院化学研究所 |
通讯作者 | Xu Yi-Zhuang |
作者单位 | 1.Peking Univ, State Key Lab Rare Earth Mat Chem & Applicat, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China 2.Henan Normal Univ, Coll Chem & Environm Sci, Xinxiang 453007, Peoples R China 3.Peking Univ, Hosp 3, Dept Crit Care Unit, Beijing 100191, Peoples R China |
推荐引用方式 GB/T 7714 | Li Hui-Zhen,Liu Shao-Xuan,Hua Xiao-Hui,et al. Studies on the Protonation Structure of Ofloxacin in Concentrated Sulfuric Acid Solutions[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2010,31(9):1747-1752. |
APA | Li Hui-Zhen.,Liu Shao-Xuan.,Hua Xiao-Hui.,Pan Qing-Hua.,Yang Zhan-Lan.,...&Wu Jin-Guang.(2010).Studies on the Protonation Structure of Ofloxacin in Concentrated Sulfuric Acid Solutions.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,31(9),1747-1752. |
MLA | Li Hui-Zhen,et al."Studies on the Protonation Structure of Ofloxacin in Concentrated Sulfuric Acid Solutions".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 31.9(2010):1747-1752. |
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