Investigations on the Interactions between Plasma Proteins and Magnetic Iron Oxide Nanoparticles with Different Surface Modifications

doi:10.1021/jp1086653

CORC > 化学研究所 > 中国科学院化学研究所

	Investigations on the Interactions between Plasma Proteins and Magnetic Iron Oxide Nanoparticles with Different Surface Modifications
	Liu, Shujie; Han, Yuchun; Qiao, Ruirui; Zeng, Jianfeng; Jia, Qiaojuan; Wang, Yilin; Gao, Mingyuan
刊名	JOURNAL OF PHYSICAL CHEMISTRY C
	2010-12-16
卷号	114 期号:49 页码:21270-21276
ISSN号	1932-7447
DOI	10.1021/jp1086653
英文摘要	Three types of magnetic iron oxide nanoparticles with various kinds of surface modifications were synthesized, and the interactions between the nanoparticles and two types of high abundant plasma proteins were investigated by isothermal titration calorimetry and dynamic light scattering (DLS) methods. It was found that these interactions were strongly dependent on the surface properties of the nanoparticles. Enthalpy-entropy analysis suggested that poly(ethylene glycol) (PEG) modification on the particle surface could effectively reduce the interactions between the magnetic nanoparticles and the plasma proteins. DLS investigations further implied that electrostatic attractions could either increase or decrease the colloidal stability of the nanoparticles, depending on the particle surface properties, which will give rise to different in vivo biodistributions for the intravenously injected nanoparticles, according to literature reports. Proper surface modifications, upon the use of PEG in combination with various types of small molecules for reducing surface charges, were found to be effective for eliminating the strong interactions between nanoparticles and proteins, which is of the utmost importance for developing iron oxide magnetic nanoparticles with long blood circulation time for in vivo applications.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000284990800048
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/69693]
专题	中国科学院化学研究所
通讯作者	Wang, Yilin
作者单位	Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Liu, Shujie,Han, Yuchun,Qiao, Ruirui,et al. Investigations on the Interactions between Plasma Proteins and Magnetic Iron Oxide Nanoparticles with Different Surface Modifications[J]. JOURNAL OF PHYSICAL CHEMISTRY C,2010,114(49):21270-21276.
APA	Liu, Shujie.,Han, Yuchun.,Qiao, Ruirui.,Zeng, Jianfeng.,Jia, Qiaojuan.,...&Gao, Mingyuan.(2010).Investigations on the Interactions between Plasma Proteins and Magnetic Iron Oxide Nanoparticles with Different Surface Modifications.JOURNAL OF PHYSICAL CHEMISTRY C,114(49),21270-21276.
MLA	Liu, Shujie,et al."Investigations on the Interactions between Plasma Proteins and Magnetic Iron Oxide Nanoparticles with Different Surface Modifications".JOURNAL OF PHYSICAL CHEMISTRY C 114.49(2010):21270-21276.