Conjugated Polymer/Porphyrin Complexes for Efficient Energy Transfer and Improving Light-Activated Antibacterial Activity

doi:10.1021/ja904492x

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	Conjugated Polymer/Porphyrin Complexes for Efficient Energy Transfer and Improving Light-Activated Antibacterial Activity
	Xing, Chengfen; Xu, Qingling; Tang, Hongwei; Liu, Libing; Wang, Shu
刊名	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
	2009-09-16
卷号	131 期号:36 页码:13117-13124
ISSN号	0002-7863
DOI	10.1021/ja904492x
英文摘要	With the increasing antibiotic resistance of microorganisms, there is a growing interest in the design and development of new materials that are effective in killing bacteria to replace conventional antibiotics. Herein, a new anionic water-soluble polythiophene (PTP) and a cationic porphyrin (TPPN) are synthesized and characterized. They can forma complex through electrostatic interactions, and efficient energy transfer from PTP to TPPN occurs upon irradiation under white light (400-800 nm). The energy of TPPN transfers to triplet by intersystem crossing, followed by sensitization of oxygen molecule to enhance the efficiency of singlet oxygen generation related to TPPN itself. The positive charges of PTP/TPPN complex promote its adsorption to the negatively charged bacteria membranes of Gram-negative Escherichia coli and Gram-positive Bacillus subtilis through electrostatic interactions, and the singlet oxygen effectively kills the bacteria. The photosensitized inactivation of bacteria for the PTP/TPPN complex is efficient, and about 70% reduction of bacterial viability is observed after only 5 min of irradiation with white light at a fluence rate of 90 mW.cm(-2) (27 J.cm(-2)). The technique provides a promising application in photodynamic inactivation of bacteria on the basis of enhanced energy transfer offered by light-harvesting conjugated polymers.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000269736000051
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/66859]
专题	中国科学院化学研究所
通讯作者	Liu, Libing
作者单位	Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Organ Solids, Inst Chem, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Xing, Chengfen,Xu, Qingling,Tang, Hongwei,et al. Conjugated Polymer/Porphyrin Complexes for Efficient Energy Transfer and Improving Light-Activated Antibacterial Activity[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2009,131(36):13117-13124.
APA	Xing, Chengfen,Xu, Qingling,Tang, Hongwei,Liu, Libing,&Wang, Shu.(2009).Conjugated Polymer/Porphyrin Complexes for Efficient Energy Transfer and Improving Light-Activated Antibacterial Activity.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,131(36),13117-13124.
MLA	Xing, Chengfen,et al."Conjugated Polymer/Porphyrin Complexes for Efficient Energy Transfer and Improving Light-Activated Antibacterial Activity".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 131.36(2009):13117-13124.