Structural effects on the conformational transition of transferrin induced by binding of flavonoids with different numbers and positions of hydroxyl groups

doi:10.1016/j.jphotochem.2007.09.014

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	Structural effects on the conformational transition of transferrin induced by binding of flavonoids with different numbers and positions of hydroxyl groups
	Du, Hongyan 1,2; Xiang, Junfeng 1; Zhang, Yazhou 1,2; Tang, Yalin 1; Xu, Guangzhi 1
刊名	JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
	2008-03-05
卷号	195 期号:1 页码:127-134
关键词	Transferrin Flavonoid Hydrogen Bonding Conformational Transition
ISSN号	1010-6030
DOI	10.1016/j.jphotochem.2007.09.014
英文摘要	The effects of conformational changes to transferrin induced by the binding of flavonoids with different numbers and positions of hydroxyl groups were explored using spectroscopic and molecular modeling methods. The flavonoid hydroxyl group is not necessary for conformation changes of transferrin. However, the binding ability was found to increase with increasing numbers of hydroxyl groups and further conformational changes were observed. By molecular modeling calculations, intermolecular energy including van der Waals and electrostatic interactions, together with hydrogen bonding are found to have important roles in binding of flavonoids to transferrin. Additionally, the positions of the hydroxyl groups also affect the binding ability because they can alter the relative acidity of the hydroxyl groups, thereby changing the hydrogen bonding ability. Our results have indicated a mechanism for the interactions between flavonoids and transferrin, and provide information for possible flavonoid modification and design of methods to deliver drug molecules via transferrin to target tissues and cells effectively. (C) 2007 Elsevier B.V. All rights reserved.
语种	英语
出版者	ELSEVIER SCIENCE SA
WOS记录号	WOS:000254324600015
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/65139]
专题	中国科学院化学研究所
通讯作者	Tang, Yalin
作者单位	1.Chinese Acad Sci, Inst Chem,BNLMS, Ctr Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Du, Hongyan,Xiang, Junfeng,Zhang, Yazhou,et al. Structural effects on the conformational transition of transferrin induced by binding of flavonoids with different numbers and positions of hydroxyl groups[J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY,2008,195(1):127-134.
APA	Du, Hongyan,Xiang, Junfeng,Zhang, Yazhou,Tang, Yalin,&Xu, Guangzhi.(2008).Structural effects on the conformational transition of transferrin induced by binding of flavonoids with different numbers and positions of hydroxyl groups.JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY,195(1),127-134.
MLA	Du, Hongyan,et al."Structural effects on the conformational transition of transferrin induced by binding of flavonoids with different numbers and positions of hydroxyl groups".JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY 195.1(2008):127-134.