Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice

doi:10.1016/j.toxlet.2008.07.020

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	Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice
	Yang, Sheng-Tao 1; Wang, Xiang 2; Jia, Guang 2; Gu, Yiqun 3; Wang, Tiancheng 4; Nie, Haiyu 1; Ge, Cuicui 5,6; Wang, Haifang 1; Liu, Yuanfang 1
刊名	TOXICOLOGY LETTERS
	2008-10-01
卷号	181 期号:3 页码:182-189
关键词	Carbon Nanotubes Intravenous Administration Accumulation Toxicity Oxidative Stress
ISSN号	0378-4274
DOI	10.1016/j.toxlet.2008.07.020
英文摘要	The biomedical application of single-walled carbon nanotubes (SWCNTs), such as drug delivery and cancer treatment, requires a clear understanding of their fate and toxicological profile after intravenous administration. In this study, the long-term accumulation and toxicity of intravenously injected SWCNTs in the main Organs (such as liver, lung and spleen) in mice were carefully studied. Although SWCNTs stayed in mice over 3 months, they showed low toxicity to mice. The long-term accumulation of SWCNTs in the main organs was evidenced by using Raman spectroscopy and TEM technique. Statistically significant changes in organ indices and serum biochemical parameters (LDH, ALT and AST) were observed. The histological observations demonstrate that slight inflammation and inflammatory cell infiltration occurred in lung, but the serum immunological indicators (CH 50 level and TNF-alpha level) remained unchanged. No apoptosis was induced in the main organs. The decreasing glutathione (GSH) level and increasing malondialdehyde (MDA) level suggest that the toxicity of SWCNTs might be due to the oxidative stress. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
语种	英语
出版者	ELSEVIER IRELAND LTD
WOS记录号	WOS:000260646100007
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/64481]
专题	中国科学院化学研究所
通讯作者	Wang, Haifang
作者单位	1.Peking Univ, Coll Chem & Mol Engn, Dept Biol Chem, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China 2.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100083, Peoples R China 3.Matern Hosp Haidian Dist, Beijing 100080, Peoples R China 4.Peking Univ, Third Hosp, Dept Clin Lab, Beijing 100083, Peoples R China 5.Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Hlth Sci Nanoscale Mat & Nanosafe, Beijing 100049, Peoples R China 6.Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Yang, Sheng-Tao,Wang, Xiang,Jia, Guang,et al. Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice[J]. TOXICOLOGY LETTERS,2008,181(3):182-189.
APA	Yang, Sheng-Tao.,Wang, Xiang.,Jia, Guang.,Gu, Yiqun.,Wang, Tiancheng.,...&Liu, Yuanfang.(2008).Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice.TOXICOLOGY LETTERS,181(3),182-189.
MLA	Yang, Sheng-Tao,et al."Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice".TOXICOLOGY LETTERS 181.3(2008):182-189.