Self-assembly of polypeptide-containing ABC-type triblock copolymers in aqueous solution and its pH dependence

doi:10.1021/bm0609792

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	Self-assembly of polypeptide-containing ABC-type triblock copolymers in aqueous solution and its pH dependence
	Sun, Jing ; Deng, Chao ; Chen, Xuesi ; Yu, Haijun ; Tian, Huayu ; Sun, Jingru ; Jing, Xiabin
刊名	BIOMACROMOLECULES
	2007-03-01
卷号	8 期号:3 页码:1013-1017
ISSN号	1525-7797
DOI	10.1021/bm0609792
英文摘要	Self-assembling of novel biodegradable ABC-type triblock copolymer poly(ethylene glycol)-poly(L-lactide)-poly(L-glutamic acid) (PEG-PLLA-PLGA) is studied. In aqueous media, it self-assembles into a spherical micelle with the hydrophobic PLLA segment in the core and the two hydrophilic segments PEG and PLGA in the shell. With the lengths of PEG and PLLA blocks fixed, the diameter of the micelles depends on the length of the PLGA block and on the volume ratio of H2O/dimethylformamide (DMF) in the media. When the PLGA block is long enough, morphology of the self-assembly is pH-dependent. It assembles into the spherical micelle in aqueous media at pH 4.5 and into the connected rod at or below pH 3.2. The critical micelle concentration (cmc) of the copolymer changes accordingly with decreasing solution pH. Both aggregation states can convert to each other at the proper pH value. This reversibility is ascribed to the dissociation and neutralization of the COOH groups in the LGA residues. When the PLGA block is short compared to the PEG or PLLA block, it assembles only into the spherical micelle at various pH values.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000244798600034
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/61545]
专题	中国科学院化学研究所
通讯作者	Jing, Xiabin
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Sun, Jing,Deng, Chao,Chen, Xuesi,et al. Self-assembly of polypeptide-containing ABC-type triblock copolymers in aqueous solution and its pH dependence[J]. BIOMACROMOLECULES,2007,8(3):1013-1017.
APA	Sun, Jing.,Deng, Chao.,Chen, Xuesi.,Yu, Haijun.,Tian, Huayu.,...&Jing, Xiabin.(2007).Self-assembly of polypeptide-containing ABC-type triblock copolymers in aqueous solution and its pH dependence.BIOMACROMOLECULES,8(3),1013-1017.
MLA	Sun, Jing,et al."Self-assembly of polypeptide-containing ABC-type triblock copolymers in aqueous solution and its pH dependence".BIOMACROMOLECULES 8.3(2007):1013-1017.