Synthesis and characterization of amphiphilic block copolymers with allyl side-groups

doi:10.1002/pola.22297

CORC > 化学研究所 > 中国科学院化学研究所

	Synthesis and characterization of amphiphilic block copolymers with allyl side-groups
	Hu, Xiuli 1,2; Chen, Xuesi 1; Xie, Zhigang 1,2; Liu, Shi 1; Jing, Xiabin 1
刊名	JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
	2007-12-01
卷号	45 期号:23 页码:5518-5528
关键词	Allyl Amphiphilic Polycarbonates Polyesters Ring-opening Polymerization
ISSN号	0887-624X
DOI	10.1002/pola.22297
英文摘要	The synthesis of a new cyclic carbonate monomer containing an allyl group was reported and its biodegradable amphiphilic block copolymer, poly(ethylene glycol)-block-poly(L-lactide-co-5-methyl-5-allyloxycarbonyl-propylene carbonate) [PEG-b-P(LA-co-MAC)] was synthesized by ring-opening polymerization (ROP) of L-lactide (LA) and 5-methyl-5-allyloxycarbonyl-1,3-dioxan-2-one (MAC) in the presence of poly (ethylene glycol) as a macroinitiator, with diethyl zinc as a catalyst. (13)C NMR and (1)H NMR were used for microstructure identification of the copolymers. The copolymer could form micelles in aqueous solution. The core of the micelles is built of the hydrophobic P(LA-co-MAC) chains, whereas the shell is set up by the hydrophilic PEG blocks. The micelles exhibited a homogeneous spherical morphology and unimodal size distribution. By using the cyclic carbonate monomer containing allyl side-groups, crosslinking of the PEG-b-P(LA-co-MAC) inner core was possible. The adhesion and spreading of ECV-304 cells on the copolymer were better than that on PLA films. Therefore, this biodegradable amphiphilic block copolymer is expected to be used as a biomaterial for drug delivery and tissue engineering. (c) 2007 Wiley Periodicals, Inc.
语种	英语
出版者	WILEY-BLACKWELL
WOS记录号	WOS:000251631100015
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/61119]
专题	中国科学院化学研究所
通讯作者	Jing, Xiabin
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Hu, Xiuli,Chen, Xuesi,Xie, Zhigang,et al. Synthesis and characterization of amphiphilic block copolymers with allyl side-groups[J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,2007,45(23):5518-5528.
APA	Hu, Xiuli,Chen, Xuesi,Xie, Zhigang,Liu, Shi,&Jing, Xiabin.(2007).Synthesis and characterization of amphiphilic block copolymers with allyl side-groups.JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,45(23),5518-5528.
MLA	Hu, Xiuli,et al."Synthesis and characterization of amphiphilic block copolymers with allyl side-groups".JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY 45.23(2007):5518-5528.