Medicated wound dressings based on poly(vinyl alcohol)/poly(N-vinyl pyrrolidone)/chitosan hydrogels

doi:10.1002/app.23344

CORC > 化学研究所 > 中国科学院化学研究所

	Medicated wound dressings based on poly(vinyl alcohol)/poly(N-vinyl pyrrolidone)/chitosan hydrogels
	Yu, HJ ; Xu, XY ; Chen, XS ; Hao, JQ ; Jing, XB
刊名	JOURNAL OF APPLIED POLYMER SCIENCE
	2006-08-15
卷号	101 期号:4 页码:2453-2463
关键词	Chitosan Diffusion Hydrogels Radiation
ISSN号	0021-8995
DOI	10.1002/app.23344
英文摘要	Poly(vinyl alcohol) /poly(N-vinyl pyrrolidone) (PVP)/chitosan hydrogels were prepared by a low-temperature treatment and subsequent Co-60 -gamma-ray irradiation and then were medicated with ciprofloxacin lactate (an antibiotic) and chitosan oligomer (molecular weight = 3000 g/mol). The gel content, swelling ratio, tensile strength, and crystallinity of the hydrogels were determined. The effects of the chitosan molecular weight, the low-temperature treatment procedure, and the radiation dosage on the hydrogel properties were examined. The molecular weight of chitosan was lowered by the irradiation, but its basic polysaccharide structure was not destroyed. Repeating the low-temperature treatment and gamma-ray irradiation caused effective physical crosslinking and chemical crosslinking, respectively, and contributed to the mechanical strength of the final hydrogels. The incorporation of PVP and chitosan resulted in a significant improvement in the equilibrium swelling ratio. and elongation ratio of the prepared hydrogels. The ciprofloxacin lactate and chitosan oligomer were soaked into the hydrogels. Their in vitro release behaviors were examined, and they were found to follow diffusion-controlled kinetics. (c) 2006 Wiley Periodicals, Inc.
语种	英语
出版者	JOHN WILEY & SONS INC
WOS记录号	WOS:000238709700043
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/59091]
专题	中国科学院化学研究所
通讯作者	Jing, XB
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Yu, HJ,Xu, XY,Chen, XS,et al. Medicated wound dressings based on poly(vinyl alcohol)/poly(N-vinyl pyrrolidone)/chitosan hydrogels[J]. JOURNAL OF APPLIED POLYMER SCIENCE,2006,101(4):2453-2463.
APA	Yu, HJ,Xu, XY,Chen, XS,Hao, JQ,&Jing, XB.(2006).Medicated wound dressings based on poly(vinyl alcohol)/poly(N-vinyl pyrrolidone)/chitosan hydrogels.JOURNAL OF APPLIED POLYMER SCIENCE,101(4),2453-2463.
MLA	Yu, HJ,et al."Medicated wound dressings based on poly(vinyl alcohol)/poly(N-vinyl pyrrolidone)/chitosan hydrogels".JOURNAL OF APPLIED POLYMER SCIENCE 101.4(2006):2453-2463.