Mechanism and Cellular Kinetic Studies of the Enhancement of Antioxidant Activity by Using Surface-Functionalized Gold Nanoparticles

doi:10.1002/chem.201203506

CORC > 化学研究所 > 中国科学院化学研究所

	Mechanism and Cellular Kinetic Studies of the Enhancement of Antioxidant Activity by Using Surface-Functionalized Gold Nanoparticles
	Du, Libo 1; Suo, Siqingaowa 1; Wang, Guangqing 1; Jia, Hongying 1; Liu, Ke Jian 2; Zhao, Baolu 3; Liu, Yang 1
刊名	CHEMISTRY-A EUROPEAN JOURNAL
	2013
卷号	19 期号:4 页码:1281-1287
关键词	Antioxidants Cytotoxicity Gold Kinetics Nanoparticles Self-assembly
ISSN号	0947-6539
DOI	10.1002/chem.201203506
英文摘要	The enhanced antioxidant activity of surface-functionalized gold nanoparticles (AuNPs) synthesized by self-assembly has attracted great attention, but little is known about the mechanism behind the enhanced activity. To address this challenge, the antioxidant activity of Au@PEG3SA (i.e., surface-functionalization of spherical AuNPs with the antioxidant salvianic acid A) was used as an example to illustrate the mechanism of the enhanced activity. Evaluation of the antioxidant activity was performed in a radical-scavenging reaction between Au@PEG3SA and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical. As expected, the rate constant for the reaction of Au@PEG3SA with DPPH was about nine times greater than that for the salvianic acid A monomer. A comparative analysis of the spectral characteristics of Au@PEG3SA and the salvianic acid A monomer further imply that the enhancement of the antioxidative reaction kinetics may be ascribed to the variation in the transition state for the DPPH-radical scavenging reaction through pp stacking interactions between and among adjacent groups on the surface of Au@PEG3SA. On the other hand, the kinetic enhancement of Au@PEG3SA on reactive-oxygen-species (ROS) scavenging can be observed in living cells and in vivo, which possibly provides new insight for the bioapplication of self-assembly of surface-functionalized AuNPs.
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000313721500018
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/54859]
专题	中国科学院化学研究所
通讯作者	Liu, Ke Jian
作者单位	1.Chinese Acad Sci, Ctr Mol Sci, State Key Lab Struct Chem Unstable Species, Inst Chem, Beijing 100190, Peoples R China 2.Univ New Mexico, Coll Pharm, Albuquerque, NM 87131 USA 3.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Du, Libo,Suo, Siqingaowa,Wang, Guangqing,et al. Mechanism and Cellular Kinetic Studies of the Enhancement of Antioxidant Activity by Using Surface-Functionalized Gold Nanoparticles[J]. CHEMISTRY-A EUROPEAN JOURNAL,2013,19(4):1281-1287.
APA	Du, Libo.,Suo, Siqingaowa.,Wang, Guangqing.,Jia, Hongying.,Liu, Ke Jian.,...&Liu, Yang.(2013).Mechanism and Cellular Kinetic Studies of the Enhancement of Antioxidant Activity by Using Surface-Functionalized Gold Nanoparticles.CHEMISTRY-A EUROPEAN JOURNAL,19(4),1281-1287.
MLA	Du, Libo,et al."Mechanism and Cellular Kinetic Studies of the Enhancement of Antioxidant Activity by Using Surface-Functionalized Gold Nanoparticles".CHEMISTRY-A EUROPEAN JOURNAL 19.4(2013):1281-1287.