Multifunctional Nanoprobe for MRI/Optical Dual-Modality Imaging and Radical Scavenging

doi:10.1002/chem.201301601

CORC > 化学研究所 > 中国科学院化学研究所

	Multifunctional Nanoprobe for MRI/Optical Dual-Modality Imaging and Radical Scavenging
	Zhen, Mingming 1; Zheng, Junpeng 1; Wang, Yifan 2; Shu, Chunying 1; Gao, Fabao 2; Zou, Jing 3; Pyykko, Ilmari 3; Wang, Chunru 1
刊名	CHEMISTRY-A EUROPEAN JOURNAL
	2013-10-18
卷号	19 期号:43 页码:14675-14681
关键词	Fluorescence Fullerenes Imaging Agents Magnetic Resonance Imaging Radical Scavengers
ISSN号	0947-6539
DOI	10.1002/chem.201301601
英文摘要	The development of novel nanomaterials for the diagnosis and/or treatment of human diseases has become an important issue. In this work, a multifunctional theranostic agent was designed by covalently binding hydroxyl-and amino-bearing C-60 derivatives (C60O-10(OH)(-16)(NH2)(-6)-(NO2)(-6)center dot 24H(2)O) with gadolinium diethylenetriaminepentaacetic acid (GdDTPA) to yield C60O-10(OH)(-16)(NH2)similar to (6)(NO2)-6 center dot 24H(2)O/(Gd-DTPA)(3) (DF1Gd3). The obtained DF1Gd3 shows more than fourfold contrast improvement over commercial Gd-DTPA along with multiwavelength fluorescent emission for dual-modality diagnosis. An inner-ear magnetic resonance imaging (MRI) study was designed as a model of biological barriers, including the blood/brain barrier (BBB) for DF1Gd3 to investigate its in vivo behavior. This revealed that the fabricated contrast agent dramatically increases the local contrast but can not cross the middle ear/inner ear barrier and endolymph/perilymph barrier in the inner ear, and thus it is also BBB-pro-hibited in normal individuals. In vivo biodistribution studies suggested that 1) DF1Gd3 could circulate in vessels for a relatively long time and is mainly eliminated through liver and kidney, 2) DF1Gd3 may potentially function as a liver-specific MRI contrast agent. Interestingly, DF1Gd3 also shows an excellent quenching effect on hydroxyl radicals, as revealed by the DMPO spin trap/ESR method. The combination of enhanced MRI/FL imaging and local treatment of lesions is unique to DF1Gd3 and potentiates the medical paradigm of " detect and treat/prevent" in combating human diseases related to reactive oxygen.
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000330288400029
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/54509]
专题	中国科学院化学研究所
通讯作者	Shu, Chunying
作者单位	1.Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Sichuan Univ, West China Hosp, Mol Imaging Lab, Dept Radiol, Chengdu 610041, Peoples R China 3.Univ Tampere, Sch Med, Dept Otolaryngol, Tampere 33520, Finland
推荐引用方式 GB/T 7714	Zhen, Mingming,Zheng, Junpeng,Wang, Yifan,et al. Multifunctional Nanoprobe for MRI/Optical Dual-Modality Imaging and Radical Scavenging[J]. CHEMISTRY-A EUROPEAN JOURNAL,2013,19(43):14675-14681.
APA	Zhen, Mingming.,Zheng, Junpeng.,Wang, Yifan.,Shu, Chunying.,Gao, Fabao.,...&Wang, Chunru.(2013).Multifunctional Nanoprobe for MRI/Optical Dual-Modality Imaging and Radical Scavenging.CHEMISTRY-A EUROPEAN JOURNAL,19(43),14675-14681.
MLA	Zhen, Mingming,et al."Multifunctional Nanoprobe for MRI/Optical Dual-Modality Imaging and Radical Scavenging".CHEMISTRY-A EUROPEAN JOURNAL 19.43(2013):14675-14681.