Ambient Aerodynamic Desorption/Ionization Method for Microparticle Mass Measurement

doi:10.1021/ac303565a

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	Ambient Aerodynamic Desorption/Ionization Method for Microparticle Mass Measurement
	Xiong, Caiqiao 1,2; Zhou, Xiaoyu 1,2; Wang, Jianing 1,2; Zhang, Ning 1,2; Peng, Wen-Ping 3; Chang, Huan-Cheng 4; Nie, Zongxiu 1,2
刊名	ANALYTICAL CHEMISTRY
	2013-05-07
卷号	85 期号:9 页码:4370-4375
ISSN号	0003-2700
DOI	10.1021/ac303565a
英文摘要	An ambient desorption/ionization method, named aerodynamic desorption (AD), was proposed for the in situ rapid mass measurement of microparticles. The AD method exploited the discontinuous atmospheric pressure interface (DAPI) to generate a pulsed airflow, which was used to desorb the microparticles under atmospheric pressure. Various microparticles, e.g, bacteria, cell, polystyrene, synthetic diamond, and silica particles, with different size and surface component were successfully desorbed. Similar to that in the conventional laser induced acoustic desorption (LIAD) method, these microparticles were desorbed as precharged ions in the AD process and the charge number was largely relevant to the particle size. However, compared with LIAD, the sensitivity of the AD method was higher. A lower concentration of particles was required for the analysis. In addition, the construction and sampling process of AD source were much simpler. All types of liquid, solid, or/and gaseous samples can be directly sampled under ambient condition. As a demonstration of this AD method, the in situ mass analysis of red blood cells (RBCs) and E. coli bacteria were carried out using a homemade ambient AD mass spectrometer consisting of AD source, QIT mass analyzer, and charge detector. Their mass and mass distributions were obtained successfully.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000318756100027
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/54155]
专题	中国科学院化学研究所
通讯作者	Nie, Zongxiu
作者单位	1.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China 2.Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 3.Natl Dong Hwa Univ, Dept Phys, Shoufeng 97401, Hualien, Taiwan 4.Acad Sinica, Inst Atom & Mol Sci, Taipei 106, Taiwan
推荐引用方式 GB/T 7714	Xiong, Caiqiao,Zhou, Xiaoyu,Wang, Jianing,et al. Ambient Aerodynamic Desorption/Ionization Method for Microparticle Mass Measurement[J]. ANALYTICAL CHEMISTRY,2013,85(9):4370-4375.
APA	Xiong, Caiqiao.,Zhou, Xiaoyu.,Wang, Jianing.,Zhang, Ning.,Peng, Wen-Ping.,...&Nie, Zongxiu.(2013).Ambient Aerodynamic Desorption/Ionization Method for Microparticle Mass Measurement.ANALYTICAL CHEMISTRY,85(9),4370-4375.
MLA	Xiong, Caiqiao,et al."Ambient Aerodynamic Desorption/Ionization Method for Microparticle Mass Measurement".ANALYTICAL CHEMISTRY 85.9(2013):4370-4375.