Glucose-responsive hydrogels based on dynamic covalent chemistry and inclusion complexation

doi:10.1039/c3sm53059k

CORC > 化学研究所 > 中国科学院化学研究所

	Glucose-responsive hydrogels based on dynamic covalent chemistry and inclusion complexation
	Yang, Ting; Ji, Ran; Deng, Xin-Xing; Du, Fu-Sheng; Li, Zi-Chen
刊名	SOFT MATTER
	2014
卷号	10 期号:15 页码:2671-2678
ISSN号	1744-683X
DOI	10.1039/c3sm53059k
英文摘要	A novel glucose-responsive hydrogel system based on dynamic covalent chemistry and inclusion complexation was described. Hydrogels are formed by simply mixing the solutions of three components: poly(ethylene oxide)-b-poly vinyl alcohol (PEO-b-PVA) diblock polymer, alpha-cyclodextrin (alpha-CD) and phenylboronic acid (PBA)-terminated PEO crosslinker. Dynamic covalent bonds between PVA and PBA provide sugar-responsive crosslinking, and the inclusion complexation between PEO and alpha-CD can promote hydrogel formation and enhance hydrogel stability. The ratios of the three components have a remarkable effect on the gelation time and the mechanical properties of the final gels. In rheological measurements, the hydrogels are demonstrated to possess solid-like behaviour and good structural recovery ability after yielding. The sugar-responsiveness of the hydrogels was examined by protein loading and release experiments, and the results indicate that this property is also dependent on the compositions of the gels; at a proper component ratio, a new glucose-responsive hydrogel system operating at physiological pH can be obtained. The combination of good biocompatibility of the three components and the easy preparation of hydrogels with tunable glucose-responsiveness may enable an alternative design of hydrogel systems that finds potential applications in biomedical and pharmaceutical fields, such as treatment of diabetes.
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000333116700021
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/53131]
专题	中国科学院化学研究所
通讯作者	Li, Zi-Chen
作者单位	Peking Univ, Coll Chem & Mol Engn, Dept Polymer Sci & Engn, BNLMS,Key Lab Polymer Chem & Phys,Minist Educ, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Yang, Ting,Ji, Ran,Deng, Xin-Xing,et al. Glucose-responsive hydrogels based on dynamic covalent chemistry and inclusion complexation[J]. SOFT MATTER,2014,10(15):2671-2678.
APA	Yang, Ting,Ji, Ran,Deng, Xin-Xing,Du, Fu-Sheng,&Li, Zi-Chen.(2014).Glucose-responsive hydrogels based on dynamic covalent chemistry and inclusion complexation.SOFT MATTER,10(15),2671-2678.
MLA	Yang, Ting,et al."Glucose-responsive hydrogels based on dynamic covalent chemistry and inclusion complexation".SOFT MATTER 10.15(2014):2671-2678.