Network pharmacology study on the mechanism of traditional Chinese medicine for upper respiratory tract infection

doi:10.1039/c4mb00164h

CORC > 化学研究所 > 中国科学院化学研究所

	Network pharmacology study on the mechanism of traditional Chinese medicine for upper respiratory tract infection
	Zhang, Xinzhuang 1; Gu, Jiangyong 2; Cao, Liang 1; Li, Na 1; Ma, Yiming 1; Su, Zhenzhen 1; Ding, Gang 1; Chen, Lirong 2; Xu, Xiaojie 2; Xiao, Wei 1
刊名	MOLECULAR BIOSYSTEMS
	2014
卷号	10 期号:10 页码:2517-2525
ISSN号	1742-206X
DOI	10.1039/c4mb00164h
英文摘要	Traditional Chinese medicine (TCM) is a multi-component and multi-target agent and could treat complex diseases in a holistic way, especially infection diseases. However, the underlying pharmacology remains unclear. Fortunately, network pharmacology by integrating system biology and polypharmacology provides a strategy to address this issue. In this work, Reduning Injection (RDN), a well-used TCM treatment in the clinic for upper respiratory tract infections (URTIs), was investigated to interpret the molecular mechanism and predict new clinical directions by integrating molecular docking, network analysis and cell-based assays. 32 active ingredients and 38 potential targets were identified. In vitro experiments confirmed the bioactivities of the compounds against lipopolysaccharide (LPS)-stimulated PGE(2) and NO production in RAW264.7 cells. Moreover, network analysis showed that RDN could not only inhibit viral replication but also alleviate the sickness symptoms of URTIs through directly targeting the key proteins in the respiratory viral life cycle and indirectly regulating host immune systems. In addition, other clinical applications of RDN such as neoplasms, cardiovascular diseases and immune system diseases were predicted on the basis of the relationships between targets and diseases.
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000341360200004
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/52459]
专题	中国科学院化学研究所
通讯作者	Chen, Lirong
作者单位	1.Kanion Pharmaceut Corp, State Key Lab New Tech Chinese Med Pharmaceut Pro, Lianyungang 222002, Peoples R China 2.Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci BNLMS, State Key Lab Rare Earth Mat Chem & Applicat, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Xinzhuang,Gu, Jiangyong,Cao, Liang,et al. Network pharmacology study on the mechanism of traditional Chinese medicine for upper respiratory tract infection[J]. MOLECULAR BIOSYSTEMS,2014,10(10):2517-2525.
APA	Zhang, Xinzhuang.,Gu, Jiangyong.,Cao, Liang.,Li, Na.,Ma, Yiming.,...&Xiao, Wei.(2014).Network pharmacology study on the mechanism of traditional Chinese medicine for upper respiratory tract infection.MOLECULAR BIOSYSTEMS,10(10),2517-2525.
MLA	Zhang, Xinzhuang,et al."Network pharmacology study on the mechanism of traditional Chinese medicine for upper respiratory tract infection".MOLECULAR BIOSYSTEMS 10.10(2014):2517-2525.