Synthesis of poly(ethylene glycol)-b-poly(N-(2-hydroxypropyl) methacrylamide) block copolymers with well-defined structures and their influence on in vivo circulation and biodistribution

doi:10.1039/c4py00681j

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	Synthesis of poly(ethylene glycol)-b-poly(N-(2-hydroxypropyl) methacrylamide) block copolymers with well-defined structures and their influence on in vivo circulation and biodistribution
	Yu, Qingsong 1,2; Dong, Chengyan 3; Zhang, Jiajing 1; Shi, Jiyun 3; Jia, Bing 3; Wang, Fan 3; Gan, Zhihua 1,2
刊名	POLYMER CHEMISTRY
	2014-10-07
卷号	5 期号:19 页码:5617-5627
ISSN号	1759-9954
DOI	10.1039/c4py00681j
英文摘要	Well-defined water-soluble block copolymers poly(ethylene glycol)-b-poly(N-(2-hydroxypropyl) methacrylamide-co-N-methacryloylglycylglycine) (PEG-b-P(H PMA-co-MAGG)) with different compositions and narrow polydispersity were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization. The in vivo blood clearance and biodistribution of copolymers with different compositions were studied in normal BALB/c mice. The results showed that the electronegative copolymers were rapidly eliminated from blood and tended to accumulate in the liver and spleen. However, the copolymers with neutral or a small amount of negative charges showed a prolonged circulation time and low non-specific organ uptake. Combined with the quantitative analysis of in vitro hepatocyte uptake, we conclude that this was due to the balance between (i) the electrostatic repulsion between the copolymer and the cell membrane and (ii) the tendency of macrophage-like cells to capture the negative charged copolymers. This work also revealed the significant roles of the PEG chain length, negative charge and molecular weight for the copolymers as anticancer drug carriers with prolonged circulation time and optimal biodistribution.
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000342481200012
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/51705]
专题	中国科学院化学研究所
通讯作者	Wang, Fan
作者单位	1.Chinese Acad Sci, Inst Chem, CAS Key Lab Engn Plast, Beijing 100190, Peoples R China 2.Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing Lab Biomat, State Key Lab Organ Inorgan Composites, Beijing 100029, Peoples R China 3.Peking Univ, Med Isotopes Res Ctr, Beijing 100191, Peoples R China
推荐引用方式 GB/T 7714	Yu, Qingsong,Dong, Chengyan,Zhang, Jiajing,et al. Synthesis of poly(ethylene glycol)-b-poly(N-(2-hydroxypropyl) methacrylamide) block copolymers with well-defined structures and their influence on in vivo circulation and biodistribution[J]. POLYMER CHEMISTRY,2014,5(19):5617-5627.
APA	Yu, Qingsong.,Dong, Chengyan.,Zhang, Jiajing.,Shi, Jiyun.,Jia, Bing.,...&Gan, Zhihua.(2014).Synthesis of poly(ethylene glycol)-b-poly(N-(2-hydroxypropyl) methacrylamide) block copolymers with well-defined structures and their influence on in vivo circulation and biodistribution.POLYMER CHEMISTRY,5(19),5617-5627.
MLA	Yu, Qingsong,et al."Synthesis of poly(ethylene glycol)-b-poly(N-(2-hydroxypropyl) methacrylamide) block copolymers with well-defined structures and their influence on in vivo circulation and biodistribution".POLYMER CHEMISTRY 5.19(2014):5617-5627.