Cinchona Alkaloid Squaramide/AgOAc Cooperatively Catalyzed Diastereo- and Enantioselective Mannich/Cyclization Cascade Reaction of Isocyanoacetates and Cyclic Trifluoromethyl Ketimines

doi:10.1021/ol502123z

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	Cinchona Alkaloid Squaramide/AgOAc Cooperatively Catalyzed Diastereo- and Enantioselective Mannich/Cyclization Cascade Reaction of Isocyanoacetates and Cyclic Trifluoromethyl Ketimines
	Zhao, Mei-Xin 1,2,3; Bi, Hong-Lei 1,2; Jiang, Rong-Hui 1,2; Xu, Xu-Wei 1,2; Shi, Min 1,2,4
刊名	ORGANIC LETTERS
	2014-09-05
卷号	16 期号:17 页码:4566-4569
ISSN号	1523-7060
DOI	10.1021/ol502123z
英文摘要	An efficient diastereo- and enantioselective Mannich-type/cyclization cascade reaction of alpha-substituted isocyanoacetates and cyclic trifluoromethyl ketimines cooperatively catalyzed by cinchona alkaloid-derived multi-hydrogen-bonding donor squaramide and AgOAc has been investigated, affording the optically active trifluoromethyl-substituted tetrahydroimidazo[1,5-c]-quinazoline derivatives in excellent yields (up to 99%) and good to excellent stereoselectivities (up to >15:1 dr, up to 9896 cc) under mild conditions.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000341344600056
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/51315]
专题	中国科学院化学研究所
通讯作者	Zhao, Mei-Xin
作者单位	1.E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China 2.E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China 3.Chinese Acad Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Mei-Xin,Bi, Hong-Lei,Jiang, Rong-Hui,et al. Cinchona Alkaloid Squaramide/AgOAc Cooperatively Catalyzed Diastereo- and Enantioselective Mannich/Cyclization Cascade Reaction of Isocyanoacetates and Cyclic Trifluoromethyl Ketimines[J]. ORGANIC LETTERS,2014,16(17):4566-4569.
APA	Zhao, Mei-Xin,Bi, Hong-Lei,Jiang, Rong-Hui,Xu, Xu-Wei,&Shi, Min.(2014).Cinchona Alkaloid Squaramide/AgOAc Cooperatively Catalyzed Diastereo- and Enantioselective Mannich/Cyclization Cascade Reaction of Isocyanoacetates and Cyclic Trifluoromethyl Ketimines.ORGANIC LETTERS,16(17),4566-4569.
MLA	Zhao, Mei-Xin,et al."Cinchona Alkaloid Squaramide/AgOAc Cooperatively Catalyzed Diastereo- and Enantioselective Mannich/Cyclization Cascade Reaction of Isocyanoacetates and Cyclic Trifluoromethyl Ketimines".ORGANIC LETTERS 16.17(2014):4566-4569.