Injectable and biodegradable supramolecular hydrogels formed by nucleobase-terminated poly(ethylene oxide)s and alpha-cyclodextrin

doi:10.1039/c3tb21475c

CORC > 化学研究所 > 中国科学院化学研究所

	Injectable and biodegradable supramolecular hydrogels formed by nucleobase-terminated poly(ethylene oxide)s and alpha-cyclodextrin
	Kuang, Huihui 1,2; He, Hongyan 1,2; Zhang, Zhiyun 1,2; Qi, Yanxin 1; Xie, Zhigang 1; Jinga, Xiabin 1; Huang, Yubin 1
刊名	JOURNAL OF MATERIALS CHEMISTRY B
	2014
卷号	2 期号:6 页码:659-667
ISSN号	2050-750X
DOI	10.1039/c3tb21475c
英文摘要	Injectable and biodegradable supramolecular hydrogels were prepared by nucleobase (adenine/thymine)terminated poly(ethylene oxide)s (A-PEG-A/T-PEG-T) and alpha-cyclodextrin (alpha-CD). The supramolecular hydrogels were thoroughly characterized by WXRD, rheometer, and SEM. The gelation time depended on the molecular weight of PEG and the concentration of polymer precursors. The rheological studies showed enhanced elastic modulus (G') of hydrogels, because of the hydrogen-bonding between A and T acting as additional network junctions. In vitro evaluation showed that the supramolecular hydrogels have acceptable biocompatibility, and are suitable for sustained and controlled release of loaded antitumor drugs. Gel formation was also confirmed when the supramolecular hydrogels were subcutaneously injected into rats. In addition, in vivo experiments employing U14 cancer cell xenograft-bearing mice showed that the intratumoral injection of a DOX-loaded A-PEG-A/T-PEG-T/alpha-CD gel inhibited tumor growth more effectively than that of free DOX, DOX-loaded PEG/alpha-CD gel, saline or gel alone. Hence, such a simple and convenient anti-cancer drug delivery system of a A-PEG-A/T-PEG-T/alpha-CD supramolecular hydrogel would be a promising candidate for many biomedical applications, especially in the area of the chemotherapy of solid tumors.
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000329936400009
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/50531]
专题	中国科学院化学研究所
通讯作者	Huang, Yubin
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Kuang, Huihui,He, Hongyan,Zhang, Zhiyun,et al. Injectable and biodegradable supramolecular hydrogels formed by nucleobase-terminated poly(ethylene oxide)s and alpha-cyclodextrin[J]. JOURNAL OF MATERIALS CHEMISTRY B,2014,2(6):659-667.
APA	Kuang, Huihui.,He, Hongyan.,Zhang, Zhiyun.,Qi, Yanxin.,Xie, Zhigang.,...&Huang, Yubin.(2014).Injectable and biodegradable supramolecular hydrogels formed by nucleobase-terminated poly(ethylene oxide)s and alpha-cyclodextrin.JOURNAL OF MATERIALS CHEMISTRY B,2(6),659-667.
MLA	Kuang, Huihui,et al."Injectable and biodegradable supramolecular hydrogels formed by nucleobase-terminated poly(ethylene oxide)s and alpha-cyclodextrin".JOURNAL OF MATERIALS CHEMISTRY B 2.6(2014):659-667.