Recent Advances on Radionuclide Labeled Hypoxia-Imaging Agents

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	Recent Advances on Radionuclide Labeled Hypoxia-Imaging Agents
	Li, Zejun; Chu, Taiwei
刊名	CURRENT PHARMACEUTICAL DESIGN
	2012-03-01
卷号	18 期号:8 页码:1084-1097
关键词	Radionuclide Tumor Hypoxia Imaging Agent Nitroimidazole Redox-sensitive Compounds
ISSN号	1381-6128
英文摘要	Hypoxic tissue exists in most of the solid tumors and hypoxia is a common character of these tumors. The existence of hypoxic tissue in the tumor decreases the efficacy of radiotherapy and chemotherapy. Radiolabeled hypoxia markers have been developed to measure the hypoxic tissue together with non-invasive imaging techniques such as PET, SPECT, and PET/CT. This offers a convenient approach to delineate the tumor providing useful information for diagnosing cancer and guiding the treatment plan. Bioreducible organic compounds have been developed as the hypoxia markers to probe tissue hypoxia noninvasively because they can be reduced and metabolized under hypoxic conditions; form adducts with cell components, and thus be trapped in the hypoxic tissue. These compounds include nitroimidazoles and other redox-sensitive compounds such as BnAO and ATSM. Different radionuclides have been used to label these compounds such as technetium-99m, iodine-123, fluorine-18, copper-64, etc. In addition, to detect hypoxia with endogenous hypoxia markers such as carbonic anhydrase IX (CA IX) and hypoxia-inducible factor-1 (HIF-1), some radiolabeled tracers have also been developed. This article is an overview of the progress in this area in the past decade including the development of radiolabeled compounds for hypoxia detection and problems associated with the hypoxia marker development.
语种	英语
出版者	BENTHAM SCIENCE PUBL LTD
WOS记录号	WOS:000304445900006
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/48543]
专题	中国科学院化学研究所
通讯作者	Chu, Taiwei
作者单位	Peking Univ, Coll Chem & Mol Engn, Radiochem & Radiat Chem Key Lab Fundamental Sci, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Li, Zejun,Chu, Taiwei. Recent Advances on Radionuclide Labeled Hypoxia-Imaging Agents[J]. CURRENT PHARMACEUTICAL DESIGN,2012,18(8):1084-1097.
APA	Li, Zejun,&Chu, Taiwei.(2012).Recent Advances on Radionuclide Labeled Hypoxia-Imaging Agents.CURRENT PHARMACEUTICAL DESIGN,18(8),1084-1097.
MLA	Li, Zejun,et al."Recent Advances on Radionuclide Labeled Hypoxia-Imaging Agents".CURRENT PHARMACEUTICAL DESIGN 18.8(2012):1084-1097.