Detection and differential diagnosis of colon cancer by a cumulative analysis of promoter methylation

doi:10.1038/ncomms2209

CORC > 化学研究所 > 中国科学院化学研究所

	Detection and differential diagnosis of colon cancer by a cumulative analysis of promoter methylation
	Yang, Qiong 1; Dong, Ying 2; Wu, Wei 1; Zhu, Chunlei 1; Chong, Hui 1; Lu, Jiangyang 2; Yu, Dehai 1; Liu, Libing 1; Lv, Fengting 1; Wang, Shu 1
刊名	NATURE COMMUNICATIONS
	2012-11-01
卷号	3
ISSN号	2041-1723
DOI	10.1038/ncomms2209
英文摘要	Alterations in the methylation of promoters of cancer-related genes are promising biomarkers for the early detection of disease. Compared with single methylation alteration, assessing combined methylation alterations can provide higher association with specific cancer. Here we use cationic conjugated polymer-based fluorescence resonance energy transfer to quantitatively analyse DNA methylation levels of seven colon cancer-related genes in a Chinese population. Through a stepwise discriminant analysis and cumulative detection of methylation alterations, we acquire high accuracy and sensitivity for colon cancer detection (86.3 and 86.7%) and for differential diagnosis (97.5 and 94%). Moreover, we identify a correlation between the CpG island methylator phenotype and clinically important parameters in patients with colon cancer. The cumulative analysis of promoter methylation alterations by the cationic conjugated polymer-based fluorescence resonance energy transfer may be useful for the screening and differential diagnosis of patients with colon cancer, and for performing clinical correlation analyses.
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000315992100041
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/47253]
专题	中国科学院化学研究所
通讯作者	Lu, Jiangyang
作者单位	1.Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Chinese Peoples Liberat Army, Gen Hosp, Affiliated Hosp 1, Beijing 100037, Peoples R China
推荐引用方式 GB/T 7714	Yang, Qiong,Dong, Ying,Wu, Wei,et al. Detection and differential diagnosis of colon cancer by a cumulative analysis of promoter methylation[J]. NATURE COMMUNICATIONS,2012,3.
APA	Yang, Qiong.,Dong, Ying.,Wu, Wei.,Zhu, Chunlei.,Chong, Hui.,...&Wang, Shu.(2012).Detection and differential diagnosis of colon cancer by a cumulative analysis of promoter methylation.NATURE COMMUNICATIONS,3.
MLA	Yang, Qiong,et al."Detection and differential diagnosis of colon cancer by a cumulative analysis of promoter methylation".NATURE COMMUNICATIONS 3(2012).