Total Synthesis of Sinensilactam A

doi:10.1021/acs.orglett.8b00380

CORC > 化学研究所 > 中国科学院化学研究所

	Total Synthesis of Sinensilactam A
	Shao, Wenbin 1; Huang, Jun 1; Guo, Kai 1; Gong, Jianxian 1; Yang, Zhen 1,2,3,4
刊名	ORGANIC LETTERS
	2018-04-06
卷号	20 期号:7 页码:1857-1860
ISSN号	1523-7060
DOI	10.1021/acs.orglett.8b00380
英文摘要	The total synthesis of naturally occurring (+/-)-sinensilactam A was achieved in 18 steps. The key steps of this work are a rhodium-catalyzed [3 + 2] cydoaddition for construction of the two all-carbon vicinal quaternary centers and a convergent and tandem condensation of the in situ generated N-acyliminium intermediate with aldehyde 20. This enabled implementation of a unified strategy for stereoselective formation; of the tetracyclic hemiaminal core of sinensilactam A in a later stage. The total syntheses of applanatumol F and C8-epi-applanatumol D are also achieved using this strategy.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000429886900039
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/46129]
专题	中国科学院化学研究所
通讯作者	Gong, Jianxian; Yang, Zhen
作者单位	1.Peking Univ, Shenzhen Grad Sch, Key Lab Chem Genom, State Key Lab Chem Oncogen, Shenzhen 518055, Peoples R China 2.Peking Univ, Minist Educ, Key Lab Bioorgan Chem & Mol Engn, Beijing 100871, Peoples R China 3.Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China 4.Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Shao, Wenbin,Huang, Jun,Guo, Kai,et al. Total Synthesis of Sinensilactam A[J]. ORGANIC LETTERS,2018,20(7):1857-1860.
APA	Shao, Wenbin,Huang, Jun,Guo, Kai,Gong, Jianxian,&Yang, Zhen.(2018).Total Synthesis of Sinensilactam A.ORGANIC LETTERS,20(7),1857-1860.
MLA	Shao, Wenbin,et al."Total Synthesis of Sinensilactam A".ORGANIC LETTERS 20.7(2018):1857-1860.