Facile Fabrication of Hierarchically Thermoresponsive Binary Polymer Pattern for Controlled Cell Adhesion

doi:10.1002/marc.201700572

CORC > 化学研究所 > 中国科学院化学研究所

	Facile Fabrication of Hierarchically Thermoresponsive Binary Polymer Pattern for Controlled Cell Adhesion
	Hou, Jianwen 1; Cui, Lele 2; Chen, Runhai 1; Xu, Xiaodong 2; Chen, Jiayue 3; Yin, Ligang 3; Liu, Jingchuan 1; Shi, Qiang 1; Yin, Jinghua 1
刊名	MACROMOLECULAR RAPID COMMUNICATIONS
	2018-03-01
卷号	39 期号:6
关键词	Binary Polymer-brush Pattern Cell Array Dysfunctional Cells Hierarchical Architecture Smart Surfaces
ISSN号	1022-1336
DOI	10.1002/marc.201700572
英文摘要	A versatile platform allowing capture and detection of normal and dysfunctional cells on the same patterned surface is important for accessing the cellular mechanism, developing diagnostic assays, and implementing therapy. Here, an original and effective method for fabricating binary polymer brushes pattern is developed for controlled cell adhesion. The binary polymer brushes pattern, composed of poly(N-isopropylacrylamide) (PNIPAAm) and poly[poly(ethylene glycol) methyl ether methacrylate] (POEGMA) chains, is simply obtained via a combination of surface-initiated photopolymerization and surface-activated free radical polymerization. This method is unique in that it does not utilize any protecting groups or procedures of backfilling with immobilized initiator. It is demonstrated that the precise and well-defined binary polymer patterns with high resolution are fabricated using this facile method. PNIPAAm chains capture and release cells by thermoresponsiveness, while POEGMA chains possess high capability to capture dysfunctional cells specifically, inducing a switch of normal red blood cells (RBCs) arrays to hemolytic RBCs arrays on the pattern with temperature. This novel platform composed of binary polymer brush pattern is smart and versatile, which opens up pathways to potential applications as microsensors, biochips, and bioassays.
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000428452100001
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/46041]
专题	中国科学院化学研究所
通讯作者	Xu, Xiaodong; Shi, Qiang
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China 2.Harbin Engn Univ, Coll Mat Sci & Chem Engn, Polymer Mat Res Ctr, Harbin 150001, Heilongjiang, Peoples R China 3.Wego Holding Co Ltd, Weihai 264210, Peoples R China
推荐引用方式 GB/T 7714	Hou, Jianwen,Cui, Lele,Chen, Runhai,et al. Facile Fabrication of Hierarchically Thermoresponsive Binary Polymer Pattern for Controlled Cell Adhesion[J]. MACROMOLECULAR RAPID COMMUNICATIONS,2018,39(6).
APA	Hou, Jianwen.,Cui, Lele.,Chen, Runhai.,Xu, Xiaodong.,Chen, Jiayue.,...&Yin, Jinghua.(2018).Facile Fabrication of Hierarchically Thermoresponsive Binary Polymer Pattern for Controlled Cell Adhesion.MACROMOLECULAR RAPID COMMUNICATIONS,39(6).
MLA	Hou, Jianwen,et al."Facile Fabrication of Hierarchically Thermoresponsive Binary Polymer Pattern for Controlled Cell Adhesion".MACROMOLECULAR RAPID COMMUNICATIONS 39.6(2018).