Structural Modeling of Chromatin Integrates Genome Features and Reveals Chromosome Folding Principle

doi:10.1038/s41598-017-02923-6

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	Structural Modeling of Chromatin Integrates Genome Features and Reveals Chromosome Folding Principle
	Xie, Wen Jun ; Meng, Luming ; Liu, Sirui ; Zhang, Ling ; Cai, Xiaoxia ; Gao, Yi Qin 1
刊名	SCIENTIFIC REPORTS
	2017-06-06
卷号	7
ISSN号	2045-2322
DOI	10.1038/s41598-017-02923-6
英文摘要	How chromosomes fold into 3D structures and how genome functions are affected or even controlled by their spatial organization remain challenging questions. Hi-C experiment has provided important structural insights for chromosome, and Hi-C data are used here to construct the 3D chromatin structure which are characterized by two spatially segregated chromatin compartments A and B. By mapping a plethora of genome features onto the constructed 3D chromatin model, we show vividly the close connection between genome properties and the spatial organization of chromatin. We are able to dissect the whole chromatin into two types of chromatin domains which have clearly different Hi-C contact patterns as well as different sizes of chromatin loops. The two chromatin types can be respectively regarded as the basic units of chromatin compartments A and B, and also spatially segregate from each other as the two chromatin compartments. Therefore, the chromatin loops segregate in the space according to their sizes, suggesting the excluded volume or entropic effect in chromatin compartmentalization as well as chromosome positioning. Taken together, these results provide clues to the folding principles of chromosomes, their spatial organization, and the resulted clustering of many genome features in the 3D space.
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000425907300001
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/45633]
专题	中国科学院化学研究所
通讯作者	Gao, Yi Qin
作者单位	1.Peking Univ, Beijing Natl Lab Mol Sci, Coll Chem & Mol Engn, Beijing 100871, Peoples R China 2.Peking Univ, Biodynam Opt Imaging Ctr, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Xie, Wen Jun,Meng, Luming,Liu, Sirui,et al. Structural Modeling of Chromatin Integrates Genome Features and Reveals Chromosome Folding Principle[J]. SCIENTIFIC REPORTS,2017,7.
APA	Xie, Wen Jun,Meng, Luming,Liu, Sirui,Zhang, Ling,Cai, Xiaoxia,&Gao, Yi Qin.(2017).Structural Modeling of Chromatin Integrates Genome Features and Reveals Chromosome Folding Principle.SCIENTIFIC REPORTS,7.
MLA	Xie, Wen Jun,et al."Structural Modeling of Chromatin Integrates Genome Features and Reveals Chromosome Folding Principle".SCIENTIFIC REPORTS 7(2017).