Self-assembled organic nanorods for dual chemo-photodynamic therapies

doi:10.1039/c8ra00067k

CORC > 化学研究所 > 中国科学院化学研究所

	Self-assembled organic nanorods for dual chemo-photodynamic therapies
	Li, Yuanyuan 1; Hu, Xiuli 2; Zheng, Xiaohua 3; Liu, Yang 4; Liu, Shi 2; Yue, Ying 1; Xie, Zhigang 2
刊名	RSC ADVANCES
	2018
卷号	8 期号:10 页码:5493-5499
ISSN号	2046-2069
DOI	10.1039/c8ra00067k
英文摘要	Photodynamic therapy (PDT) and chemotherapy have been extensively developed as effective approaches against cancer. Herein, we constructed organic nanorods by rational co-assembly of photosensitizer, di-iodinated borondipyrromethene (BDP-I-2), and chemical anticancer drug, paclitaxel (PTX). The physico-and photochemical properties of the obtained nanorods were carefully investigated. BDP-I-2 was selected for its high singlet oxygen (O-1(2)) quantum yields. And the corresponding O-1(2) generation ability and photodynamic effect were evaluated both in vitro and in vivo. The accelerated endosomal escape of the nanorods induced by the photodynamic effect enhanced the chemotherapeutic efficacy of PTX. We believe that this synergetic nanomedicine represents a new development for antitumor chemophotodynamic therapy.
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000424024200049
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/45549]
专题	中国科学院化学研究所
通讯作者	Hu, Xiuli; Yue, Ying
作者单位	1.Jilin Univ, Hosp 1, Xinmin St, Changchun 130021, Jilin, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China 3.Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China 4.Northeast Normal Univ, Dept Chem, 5268 Renmin St, Changchun 130024, Jilin, Peoples R China
推荐引用方式 GB/T 7714	Li, Yuanyuan,Hu, Xiuli,Zheng, Xiaohua,et al. Self-assembled organic nanorods for dual chemo-photodynamic therapies[J]. RSC ADVANCES,2018,8(10):5493-5499.
APA	Li, Yuanyuan.,Hu, Xiuli.,Zheng, Xiaohua.,Liu, Yang.,Liu, Shi.,...&Xie, Zhigang.(2018).Self-assembled organic nanorods for dual chemo-photodynamic therapies.RSC ADVANCES,8(10),5493-5499.
MLA	Li, Yuanyuan,et al."Self-assembled organic nanorods for dual chemo-photodynamic therapies".RSC ADVANCES 8.10(2018):5493-5499.