Targeted delivery of a guanidine-pendant Pt(IV)-backboned poly-prodrug by an anisamide-functionalized polypeptide

doi:10.1039/c7tb02513k

CORC > 化学研究所 > 中国科学院化学研究所

	Targeted delivery of a guanidine-pendant Pt(IV)-backboned poly-prodrug by an anisamide-functionalized polypeptide
	Li, Shao-Lu 1,2; Wang, Yaoyi 2; Zhang, Jingfang 2; Wei, Wei 3; Lu, Hua 2
刊名	JOURNAL OF MATERIALS CHEMISTRY B
	2017-12-28
卷号	5 期号:48 页码:9546-9557
ISSN号	2050-750X
DOI	10.1039/c7tb02513k
英文摘要	We describe here a novel targeting polyion complex (Tg-PIC) system for the delivery and intracellular release of cisplatin. Briefly, a guanidinium-pendant Pt(IV)-backboned poly-prodrug termed P(DSP-Gu) is prepared with excellent aqueous solubility, high drug-loading and high potency. To enable prolonged circulation and selective cellular internalization, P(DSP-Gu) is complexed with anisamide-end-capped poly(ethylene glycol)-block-poly(L-phosphotyrosine)-block-poly(L-leucine) (AA-PEG-PpY-PLeu) to yield Tg-PIC via electrostatic coacervation. Tg-PIC is stabilized by hydrogen bonding between phosphate and guanidinium, the PEG corona, and the helical poly(L-leucine) segment forming the hydrophobic core. The anisamide group, a high affinity ligand recognizing the sigma (sigma) receptors that are overexpressed on many human malignancies including prostate cancer, is incorporated at the surface of the Tg-PIC for active targeting and efficient internalization. In vitro, the Tg-PICs show targeted and efficient internalization into sigma receptor-positive PC3 cells, and can release toxic Pt(II) species due to the degradation of P(DSP-Gu) under the intracellular reducing conditions. In vivo, the Tg-PICs exhibit superior antitumor efficacy with reduced toxicity. Thus, the system holds considerable promise towards more effective and safe nanomedicine.
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000418072200012
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/45227]
专题	中国科学院化学研究所
通讯作者	Wei, Wei; Lu, Hua
作者单位	1.Tianjin Polytech Univ, Sch Mat Sci & Engn, State Key Lab Separat Membranes & Membrane Proc, Tianjin 300387, Peoples R China 2.Peking Univ, Key Lab Polymer Chem & Phys, Beijing Natl Lab Mol Sci,Minist Educ, Ctr Soft Matter Sci & Engn,Coll Chem & Mol Engn, Beijing 100871, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 10090, Peoples R China
推荐引用方式 GB/T 7714	Li, Shao-Lu,Wang, Yaoyi,Zhang, Jingfang,et al. Targeted delivery of a guanidine-pendant Pt(IV)-backboned poly-prodrug by an anisamide-functionalized polypeptide[J]. JOURNAL OF MATERIALS CHEMISTRY B,2017,5(48):9546-9557.
APA	Li, Shao-Lu,Wang, Yaoyi,Zhang, Jingfang,Wei, Wei,&Lu, Hua.(2017).Targeted delivery of a guanidine-pendant Pt(IV)-backboned poly-prodrug by an anisamide-functionalized polypeptide.JOURNAL OF MATERIALS CHEMISTRY B,5(48),9546-9557.
MLA	Li, Shao-Lu,et al."Targeted delivery of a guanidine-pendant Pt(IV)-backboned poly-prodrug by an anisamide-functionalized polypeptide".JOURNAL OF MATERIALS CHEMISTRY B 5.48(2017):9546-9557.