Compact Vesicles Self-Assembled from Binary Graft Copolymers with High Hydrophilic Fraction for Potential Drug/Protein Delivery

doi:10.1021/acsmacrolett.7b00549

CORC > 化学研究所 > 中国科学院化学研究所

	Compact Vesicles Self-Assembled from Binary Graft Copolymers with High Hydrophilic Fraction for Potential Drug/Protein Delivery
	Wang, Yupeng 1,2; Wang, Lina 1,3; Li, Bin 4; Cheng, Yanxiang 1; Zhou, Dongfang 1; Chen, Xuesi 1; Jing, Xiabin 1; Huang, Yubin 1
刊名	ACS MACRO LETTERS
	2017-11-01
卷号	6 期号:11 页码:1186-1190
ISSN号	2161-1653
DOI	10.1021/acsmacrolett.7b00549
英文摘要	Hollow vesicles self-assembled from amphiphilic copolymers are of great interest in biomedicine field as drug and protein carriers. Efficient preparation of polymeric vesicles with high stability in vivo is highly desirable. Herein, a novel cooperative self-assembly of two graft copolymers (GCPs) with reversed hydrophilic-hydrophobic segments is investigated to achieve morphology control for biomedical application. Interestingly, nanosized vesicles are obtained for the binary system with relatively high hydrophilic fraction (f(hydrophilic), similar to 60%), contrary to what is found in its single-component counterpart. The cooperative self-assembly endowed the hybrid vesicles with excellent resistance to protein adsorption, prolonged blood circulation time, as well as low leakage of hydrophilic drugs/proteins. Furthermore, the biological activity of the protein is well preserved inside the cooperative vesicles, making it a promising candidate as the protein carrier.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000416500000002
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/45025]
专题	中国科学院化学研究所
通讯作者	Li, Bin; Zhou, Dongfang; Huang, Yubin
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Tianjin Univ, Sch Mat Sci & Engn, Tianjin 300072, Peoples R China 4.Univ Southern Calif, Dept Chem, Los Angeles, CA 90089 USA
推荐引用方式 GB/T 7714	Wang, Yupeng,Wang, Lina,Li, Bin,et al. Compact Vesicles Self-Assembled from Binary Graft Copolymers with High Hydrophilic Fraction for Potential Drug/Protein Delivery[J]. ACS MACRO LETTERS,2017,6(11):1186-1190.
APA	Wang, Yupeng.,Wang, Lina.,Li, Bin.,Cheng, Yanxiang.,Zhou, Dongfang.,...&Huang, Yubin.(2017).Compact Vesicles Self-Assembled from Binary Graft Copolymers with High Hydrophilic Fraction for Potential Drug/Protein Delivery.ACS MACRO LETTERS,6(11),1186-1190.
MLA	Wang, Yupeng,et al."Compact Vesicles Self-Assembled from Binary Graft Copolymers with High Hydrophilic Fraction for Potential Drug/Protein Delivery".ACS MACRO LETTERS 6.11(2017):1186-1190.