Targeted and imaging-guided in vivo photodynamic therapy for tumors using dual-function, aggregation-induced emission nanoparticles

doi:10.1007/s12274-017-1906-7

CORC > 化学研究所 > 中国科学院化学研究所

	Targeted and imaging-guided in vivo photodynamic therapy for tumors using dual-function, aggregation-induced emission nanoparticles
	Sun, Xianhe 1; Zebibula, Abudureheman 2; Dong, Xiaobiao 3; Li, Gonghui 2; Zhang, Guanxin 3; Zhang, Deqing 3; Qian, Jun 1; He, Sailing 1,4
刊名	NANO RESEARCH
	2018-05-01
卷号	11 期号:5 页码:2756-2770
关键词	Aggregation-induced Emission Targeted Therapy Imaging-guided Therapy Photodynamic Therapy Tumor
ISSN号	1998-0124
DOI	10.1007/s12274-017-1906-7
英文摘要	Imaging-guided photodynamic therapy (PDT) has been regarded as a promising strategy for precise cancer treatment. Because of their excellent modifiability and drug-loading capacity, nanoparticles have played an important role in PDT. Nonetheless, when traditional photosensitizers are made into nanoparticles, both their fluorescence and reactive oxygen species generation efficacy decrease due to a phenomenon known as aggregation-caused quenching. Fortunately, in recent years, several kinds of organic dyes with "abnormal" properties (termed aggregation-induced emission, AIE) were developed. With enhanced fluorescence emission in the nanoaggregation state, the traditional obstacles mentioned above may be overcome by AIE luminogens. Herein, we provide a better combination of photosensitizers and nanoparticles, namely, dual-function AIE nanoparticles capable of producing reactive oxygen species, to implement targeted and imaging-guided in vivo PDT. Good contrast of in vivo imaging and obvious therapeutic efficacy were observed at a low dose of AIE nanoparticles and low irradiance of light, thus resulting in negligible side effects. Our work shows that AIE nanoparticles may play a promising role in imaging-guided clinical PDT for cancer in the near future.
语种	英语
出版者	TSINGHUA UNIV PRESS
WOS记录号	WOS:000431999700040
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/42841]
专题	中国科学院化学研究所
通讯作者	Li, Gonghui; Zhang, Guanxin; He, Sailing
作者单位	1.Zhejiang Univ, Ctr Opt & Electromagnet Res, State Key Lab Modern Opt Instrumentat, Hangzhou 310058, Zhejiang, Peoples R China 2.Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Urol, Coll Med, Hangzhou 310016, Zhejiang, Peoples R China 3.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, CAS Key Labs Organ Solids & Analyt Chem Living Bi, Beijing 100190, Peoples R China 4.Royal Inst Technol, Sch Elect Engn, OSQULDAS VAG 6, SE-10044 Stockholm, Sweden
推荐引用方式 GB/T 7714	Sun, Xianhe,Zebibula, Abudureheman,Dong, Xiaobiao,et al. Targeted and imaging-guided in vivo photodynamic therapy for tumors using dual-function, aggregation-induced emission nanoparticles[J]. NANO RESEARCH,2018,11(5):2756-2770.
APA	Sun, Xianhe.,Zebibula, Abudureheman.,Dong, Xiaobiao.,Li, Gonghui.,Zhang, Guanxin.,...&He, Sailing.(2018).Targeted and imaging-guided in vivo photodynamic therapy for tumors using dual-function, aggregation-induced emission nanoparticles.NANO RESEARCH,11(5),2756-2770.
MLA	Sun, Xianhe,et al."Targeted and imaging-guided in vivo photodynamic therapy for tumors using dual-function, aggregation-induced emission nanoparticles".NANO RESEARCH 11.5(2018):2756-2770.