Oligo(p-phenylenevinylene) Derivative-Incorporated and Enzyme-Responsive Hybrid Hydrogel for Tumor Cell-Specific Imaging and Activatable Photodynamic Therapy

doi:10.1021/acsbiomaterials.7b00610

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	Oligo(p-phenylenevinylene) Derivative-Incorporated and Enzyme-Responsive Hybrid Hydrogel for Tumor Cell-Specific Imaging and Activatable Photodynamic Therapy
	Li, Meng; He, Ping; Li, Shengliang; Wang, Xiaoyu; Liu, Libing; Lv, Fengting; Wang, Shu
刊名	ACS BIOMATERIALS SCIENCE & ENGINEERING
	2018-06-01
卷号	4 期号:6 页码:2037-2045
关键词	Conjugated Oligomer Responsive Hydrogel Cell Imaging Photodynamic Therapy
ISSN号	2373-9878
DOI	10.1021/acsbiomaterials.7b00610
英文摘要	Tumor-cell targeted and subcellular organelles-specific photo-sensitizer is imperative for high-efficiency photodynamic therapy (PDT). Herein, we designed and synthesized a new conjugated oligomer, oligo(p-phenylenevinylene-co-benzothiazole) (OPVBT), which could be used as photosensitizer to generate reactive oxygen species (ROS) upon light illumination. Advantageously, OPVBT was found to specifically accumulate in mitochondria, which is beneficial for effective subcellular organelles-targeted PDT. A biocompatible and biodegradable hydrogel was constructed based on Michael-type addition between cysteine-terminated matrix metalloproteinase (MMP)-cleavable oligopeptides and 4-arm vinyl sulfone-terminated poly-(ethylene glycol) (PEG-VS). By functionalizing hydrogel with OPVBT and cell adhesion peptide motif RGD, cell attachment and spreading on the hydrogel were easily realized. More importantly, because of the MMP-sensitivity of the hydrogel, tumor cells could be specifically lighted up by OPVBT liberated from the hydrogel and the growth of tumor cells are further restrained by ROS generated from OPVBT upon light illumination. The hybrid hydrogel provides a new platform for tumor-specific imaging and killing, which shows good potential for constructing targeted PDT system with reduced side effects.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000435226300013
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/42635]
专题	中国科学院化学研究所
通讯作者	Liu, Libing; Wang, Shu
作者单位	Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, Key Lab Organ Solids, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Li, Meng,He, Ping,Li, Shengliang,et al. Oligo(p-phenylenevinylene) Derivative-Incorporated and Enzyme-Responsive Hybrid Hydrogel for Tumor Cell-Specific Imaging and Activatable Photodynamic Therapy[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2018,4(6):2037-2045.
APA	Li, Meng.,He, Ping.,Li, Shengliang.,Wang, Xiaoyu.,Liu, Libing.,...&Wang, Shu.(2018).Oligo(p-phenylenevinylene) Derivative-Incorporated and Enzyme-Responsive Hybrid Hydrogel for Tumor Cell-Specific Imaging and Activatable Photodynamic Therapy.ACS BIOMATERIALS SCIENCE & ENGINEERING,4(6),2037-2045.
MLA	Li, Meng,et al."Oligo(p-phenylenevinylene) Derivative-Incorporated and Enzyme-Responsive Hybrid Hydrogel for Tumor Cell-Specific Imaging and Activatable Photodynamic Therapy".ACS BIOMATERIALS SCIENCE & ENGINEERING 4.6(2018):2037-2045.